Development of chemically modified electrodes for the voltammetric determination of cocaine, MDMA, LSD, and D-9-tetrahydrocannabinol in samples of forensic interest

• Grant number: 12/00084-7
• Support Opportunities: Regular Research Grants
• Start date: May 01, 2012
• End date: April 30, 2014
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Analytical Chemistry
• Principal Investigator: Marcelo Firmino de Oliveira
• Grantee: Marcelo Firmino de Oliveira
• Host Institution: Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto (FFCLRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Abstract

This project aims the research and development of transducers for the voltammetric determination of cocaine, MDMA (the main psychoactive component of ecstasy), LSD and D-9-tetrahydrocannabinol (the main psychoactive component of marijuana) in samples of narcotics seized by the police. Considering the fact that all these species show electrochemical response by chemical oxidation or reduction in conventional electrode surface (solid electrodes or Hg without chemical modification of surface), this project proposes the chemical modification of electrode surface by thin films, using electrodeposition, dip coating or spin coating processes. As surface modifiers, fourteen Schiff bases will be used (Salen and Salcn structures) with different cations anchored at them (Co, Fe, Cu, Ni, V and U), and will be investigated also three species of cucurbiturils. Improved selectivity and chemical specificity are expected with these surface modifications, as well as an increase in the amperometric sensitivity for these analytes. In the subsequent step, the chemical films that present the best results in terms of selectivity and specificity should be used in two different fronts, namely: 1) surface modification of screen printed electrodes, in order to obtain portable devices for application in field; 2) surface modification of the electrode of flow electrochemical cell detector of the HPLC equipment, for laboratory analysis. (AU)

Scientific publications

(7)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MARCO A. BALBINO; IZABEL C. ELEOTÉRIO; LAURA S. DE OLIVEIRA; MATHEUS M. T. DE MENEZES; JOSÉ FERNANDO DE ANDRADE; ANTÔNIO JOSÉ IPÓLITO; MARCELO F. DE OLIVEIRA. A comparative study between two different conventional working electrodes for detection of Δ9-tetrahydrocannabinol using square-wave voltammetry: a new sensitive method for forensic analysis. Journal of the Brazilian Chemical Society, v. 25, n. 3, p. 589-596, 2014-03-00. (12/00084-7)

MUZETTI RIBEIRO, MARIA FERNANDA; DA CRUZ JUNIOR, JOSE WILMO; DOCKAL, EDWARD RALPH; MCCORD, BRUCE ROYSTON; DE OLIVEIRA, MARCELO FIRMINO. Voltammetric Determination of Cocaine Using Carbon Screen Printed Electrodes Chemically Modified with Uranyl Schiff Base Films. Electroanalysis, v. 28, n. 2, p. 320-326, FEB 2016. (12/00084-7, 13/17630-7)

BALBINO, MARCO A.; ELEOTERIO, IZABEL C.; DE OLIVEIRA, LAURA S.; DE MENEZES, MATHEUS M. T.; DE ANDRADE, JOSE FERNANDO; IPOLITO, ANTONIO JOSE; DE OLIVEIRA, MARCELO F.. A Comparative Study Between Two Different Conventional Working Electrodes for Detection of Delta(9)-Tetrahydrocannabinol Using Square-Wave Voltammetry: a New Sensitive Method for Forensic Analysis. Journal of the Brazilian Chemical Society, v. 25, n. 3, p. 589-596, MAR 2014. (12/00084-7)

TADINI, MARAINE CATARINA; BALBINO, MARCO ANTONIO; ELEOTERIO, IZABEL CRISTINA; DE OLIVEIRA, LAURA SIQUEIRA; DIAS, LUIS GUSTAVO; DEMETS, GREGOIRE JEAN-FRANCOIS; DE OLIVEIRA, MARCELO FIRMINO. Developing electrodes chemically modified with cucurbit[6]uril to detect 3,4-methylenedioxymethamphetamine (MDMA) by voltammetry. Electrochimica Acta, v. 121, p. 188-193, MAR 1 2014. (12/17602-0, 12/00084-7)

DE OLIVEIRA, LAURA SIQUEIRA; DOS SANTOS POLES, ANA PAULA; BALBINO, MARCO ANTONIO; TELES DE MENEZES, MATHEUS MANOEL; DE ANDRADE, JOSE FERNANDO; DOCKAL, EDWARD RALPH; TRISTAO, HELOISA MARIA; DE OLIVEIRA, MARCELO FIRMINO. Voltammetric Determination of Cocaine in Confiscated Samples Using a Carbon Paste Electrode Modified with Different [UO2(X-MeOsalen)(H2O)]center dot H2O Complexes. SENSORS, v. 13, n. 6, p. 7668-7679, JUN 2013. (12/00084-7)

BALBINO, MARCO A.; DE OLIVEIRA, LAURA S.; ELEOTERIO, IZABEL C.; OIYE, ERICA N.; RIBEIRO, MARIA F. M.; MCCORD, BRUCE R.; IPOLITO, ANTONIO J.; DE OLIVEIRA, MARCELO F.. The Application of Voltammetric Analysis of Delta(9)-THC for the Reduction of False Positive Results in the Analysis of Suspected Marijuana Plant Matter. JOURNAL OF FORENSIC SCIENCES, v. 61, n. 4, p. 1067-1073, JUL 2016. (12/00084-7)

TELES DE MENEZES, MATHEUS MANOEL; DE ANDRADE, JOSE FERNANDO; DE OLIVEIRA, MARCELO FIRMINO; TRISTAO, HELOISA MARIA; SACZK, ADELIR APARECIDA; OKUMURA, LEONARDO LUIZ. Analysis Delta 9-THC in cosmetics by high performance liquid chromatography with UV-Vis detection. BRAZILIAN JOURNAL OF ANALYTICAL CHEMISTRY, v. 2, n. 8, p. 4-pg., 2012-04-01. (12/00084-7)