Selective denervation of the sinus node and the atrioventricular node for treatment of neurologically mediated syncope

• Grant number: 12/00559-5
• Support Opportunities: Regular Research Grants
• Start date: May 01, 2012
• End date: April 30, 2014
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Denise Tessariol Hachul
• Grantee: Denise Tessariol Hachul
• Host Institution: Instituto do Coração Professor Euryclides de Jesus Zerbini (INCOR). Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
• Associated researchers: Martina Battistini Pinheiro ; Mirella Esmanhotto Facin ; Talita Aparecida Ayres Barbosa

Abstract

The protocol consists of a prospective study in which 20 patients studied are divided into two groups randomly. All will be evaluated by invasive electrophysiological study to assess the integrity of the conduction system and to exclude the presence of tachyarrhythmias. The group randomly selected for treatment will then be submitted to selective denervation of the sinus node and atrioventricular node. All will receive dietary and behavioral guidelines for the treatment of NMS and when deemed necessary, specific outpatient drugs are indicated to the researcher responsible for the clinical assessment of patients. The evaluation results will be reviewed by two other researchers who have access to information obtained from the patients and have the responsibility to stop the experiment if there is no benefit of the patient or in case of any adverse effects being induced by the technique of denervation. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

RIVAROLA, ESTEBAN W.; HACHUL, DENISE; WU, TAN; PISANI, CRISTIANO; HARDY, CARINA; RAIMUNDI, FABRIZIO; MELO, SISSY; DARRIEUX, FRANCISCO; SCANAVACCA, MAURICIO. Targets and End Points in Cardiac Autonomic Denervation Procedures. CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY, v. 10, n. 2, FEB 2017. (12/00559-5)