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Impact of right ventricular estimulation on ventricular function in chagasic cardiomyopathy

Grant number: 12/17443-0
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): November 01, 2012
Effective date (End): October 31, 2013
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal researcher:Martino Martinelli Filho
Grantee:Rodrigo de Oliveira Madia
Home Institution: Instituto do Coração Professor Euryclides de Jesus Zerbini (INCOR). Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil

Abstract

Chagasic cardiomyopathy (CCC) is the most important manifestation of Chagas disease, and heart failure (HF) is the leading cause of death; ventricular arrhythmia and advanced atrioventricular block (AVB) are also common and can cause sudden death. To treat the irreversible AVB, a permanent pacemaker (PPM) implantantion is the only alternative, but can cause worsening of HF. Objective: to evaluate the impact of pacing on ventricular function and clinical outcome of patients with Chagas' heart disease and advanced atrioventricular block in long-term monitoring. Primary outcome: changes in left ventricular end-systolic volume index. Secundary outcomes: change in functional class of HF, change in ejection fraction and pacemaker programming. Methods: Clinical observational study, extension of a study designed for risk stratification in Chagas disease patients with PPM. One hundred patients with PPM for at least one year, indicated by CCC and advanced AVB will be selected and evaluated retrospectively. Clinical and echocardiographic findings before and after implantation will be compared and submitted to statistical analysis. Expected Results: To determine predictors related to clinical and / or echocardiographic changes in pacemaker dependent chagasic patients.