Exercise for asthmatic and COPD patients: how much do they perform and which are the real benefits?

• Grant number: 11/51782-3
• Support Opportunities: Regular Research Grants
• Start date: April 01, 2012
• End date: March 31, 2014
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Agreement: University of Toronto and University of Western Ontario
• Principal Investigator: Milton de Arruda Martins
• Grantee: Milton de Arruda Martins
• Principal researcher abroad: Dina Brooks
• Institution abroad: University of Toronto (U of T), Canada
• Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Asthma and COPD have an increased prevalence representing important problems in public health. This project aims to study mechanisms involved in airway inflammation and remodeling as well as hyperresponsiveness in these diseases due to life style and environmental stimuli. The effect of exercise and pollution will be investigated in patients as well as in murine models (translational study). There will be used functional respiratory evaluations (metabolic cart, moviment sensor), pulmonary mechanics measurements (optoeletronic plethysmography and in vivo mechanics), airway and systemic inflammation (breath condensate, cytospin, ELISA, luminex and immunohistochemistry), airway remodeling (hystological analysis) and mollecular biology techniques to quantify gene expression. An equipment to exposure animals to smoke cigarette will also be developed. It will be studied the role of exercise (physical inactivity and exercise training) in asthma and COPD disease control, airway inflammation, psychosocial aspects and health related quality of life will also be performed. At the end of this study, we intend to explain many aspects of enviromental stimuli (exercise and pollution) modify the disease evolution and… (AU)