On the mesoscopic mechanisms of tumor growth

• Grant number: 12/03823-5
• Support Opportunities: Regular Research Grants
• Start date: June 01, 2012
• End date: November 30, 2014
• Field of knowledge: Physical Sciences and Mathematics - Physics - Condensed Matter Physics
• Principal Investigator: Marco Antonio Alves da Silva
• Grantee: Marco Antonio Alves da Silva
• Host Institution: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Abstract

Our field of expertise is physics applied to medicine, and biology, involving diffusive processes. In this project, we will discuss the problem of the in vitro tumour growth, extension of some work that we have advised. The project is divided into experimental and theoretical parts, which are complementary each other. The theory will help in the search and analysis of the key mechanisms that the experiments can reveal; to this end, we use a stochastic-deterministic approach to the growth rate, cell deformation, cell cycle and the scaling exponents, as they are affected and how they contribute to the understanding of the observed phenomena. The experimental part consists in cell cultivation and observation on the growth characteristics (the average radius, number of cells and cells deformation). To this end, we need a microscope equipped with camera and computer with specific software for this purpose. (AU)

Scientific publications

(5)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

COSTA, F. H. S.; CAMPOS, M.; DA SILVA, M. A. A.. The universal growth rate behavior and regime transition in adherent cell colonies. Journal of Theoretical Biology, v. 387, p. 181-188, DEC 21 2015. (12/03823-5)

COSTA, F. H. S.; CAMPOS, M.; AIELLO, O. E.; DA SILVA, M. A. A.. Basic ingredients for mathematical modeling of tumor growth in vitro: Cooperative effects and search for space. Journal of Theoretical Biology, v. 337, p. 24-29, NOV 21 2013. (12/03823-5)

GRANZOTTI, C. R. F.; RIBEIRO, F. L.; MARTINEZ, A. S.; DA SILVA, M. A. A.. Persistence length convergence and universality for the self-avoiding random walk. Journal of Physics A-Mathematical and Theoretical, v. 52, n. 7, FEB 15 2019. (16/03918-7, 12/03823-5, 11/06757-0)

GRANZOTTI, C. R. F.; MARTINEZ, A. S.; DA SILVA, M. A. A.. Scaling analysis of random walks with persistence lengths: Application to self-avoiding walks. PHYSICAL REVIEW E, v. 93, n. 5, p. 6-pg., 2016-05-09. (11/06757-0, 12/03823-5)

GRANZOTTI, C. R. F.; MARTINEZ, A. S.; DA SILVA, M. A. A.. Scaling analysis of random walks with persistence lengths: Application to self-avoiding walks. Physical Review E, v. 93, n. 5, MAY 9 2016. (11/06757-0, 12/03823-5)