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Mathematical modeling of the biological effects of ionizing radiation in cancer cells in vitro

Grant number: 16/09370-3
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): August 01, 2016
Effective date (End): September 30, 2018
Field of knowledge:Interdisciplinary Subjects
Principal Investigator:Diego Samuel Rodrigues
Grantee:Vanessa Ulisses Amorim da Silva
Home Institution: Instituto de Biociências (IBB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil

Abstract

It is about the study and computational implementation of a mathematical model for the cancer cell growth response to the ionizing electromagnetic radiation. Its novelty is the use of in vitro biological data of the radiotherapy effect in MCF-7 cancer cell cultures (human breast cancer). The project is aligned with a research of the advisor in which there are scientific collaborations in radiotherapy and experimental cancer biology areas valuing the interdisciplinary among mathematics, computer science, biology an physics. A potential use of the modeling is the elucidation of radiotherapy mechanisms of inhibition of cell growth.