Translational control in the nervous system: tumor mechanisms

• Grant number: 12/04370-4
• Support Opportunities: Regular Research Grants
• Duration: June 01, 2012 - November 30, 2014
• Field of knowledge: Biological Sciences - Morphology - Cytology and Cell Biology
• Principal Investigator: Glaucia Noeli Maroso Hajj
• Grantee: Glaucia Noeli Maroso Hajj
• Host Institution: A C Camargo Cancer Center. Fundação Antonio Prudente (FAP). São Paulo , SP, Brazil
• Associated researchers: Dirce Maria Carraro ; Elisa Napolitano e Ferreira ; Vilma Regina Martins

Abstract

Cellular processes such as differentiation and proliferation depend on the correct control of the translation of mRNAs, thus changes in the pathways that regulate translation may be an important part of the malignant cell transformation process. Glioblastoma multiforme (GBM) is among the most aggressive tumor types and present low response rates to chemotherapeutic agents. Thus, to elucidate changes in the control of translation in GBM is of great interest to understand the biology of these tumors and facilitate the discovery of new therapies. (AU)

Scientific publications

(5)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

ROFFE, MARTIN; LUPINACCI, FERNANCLA C.; SOARES, LUANA C.; HAJJ, GLAUCIA N.; MARTINS, VILMA R.. Two widely used RSK inhibitors, BI-D1870 and SL0101, alter mTORC1 signaling in a RSK-independent manner. CELLULAR SIGNALLING, v. 27, n. 8, p. 1630-1642, AUG 2015. (13/25025-6, 11/21350-4, 13/03315-2, 09/14027-2, 12/04370-4)

HAJJ, GLAUCIA N. M.; ARANTES, CAMILA P.; SALLES DIAS, MARCOS VINICIOS; ROFFE, MARTIN; COSTA-SILVA, BRUNO; LOPES, MARILENE H.; PORTO-CARREIRO, ISABEL; RABACHINI, TATIANA; LIMA, FLAVIA R.; BERALDO, FLAVIO H.; et al. The unconventional secretion of stress-inducible protein 1 by a heterogeneous population of extracellular vesicles. CELLULAR AND MOLECULAR LIFE SCIENCES, v. 70, n. 17, p. 3211-3227, SEP 2013. (09/14027-2, 12/04370-4)

OSTAPCHENKO, VALERIY G.; BERALDO, FLAVIO H.; MOHAMMAD, AMRO H.; XIE, YU-FENG; HIRATA, PEDRO H. F.; MAGALHAES, ANA C.; LAMOUR, GUILLAUME; LI, HONGBIN; MACIEJEWSKI, ANDRZEJ; BELROSE, JILLIAN C.; et al. The Prion Protein Ligand, Stress-Inducible Phosphoprotein 1, Regulates Amyloid-beta Oligomer Toxicity. JOURNAL OF NEUROSCIENCE, v. 33, n. 42, p. 16552-16564, OCT 16 2013. (09/14027-2, 12/04370-4)

ALVARENGA, ARTHUR W.; COUTINHO-CAMILLO, CLAUDIA M.; RODRIGUES, BRUNA R.; ROCHA, RAFAEL M.; TORRES, LUIZ FERNANDO B.; MARTINS, VILMA R.; DA CUNHA, ISABELA W.; HAJJ, GLAUCIA N. M.. A Comparison between Manual and Automated Evaluations of Tissue Microarray Patterns of Protein Expression. JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, v. 61, n. 4, p. 272-282, APR 2013. (09/14027-2, 12/04370-4)

BERTONHA, FERNANDA BERNARDI; BARROS FILHO, MATEUS DE CAMARGO; KUASNE, HELLEN; DOS REIS, PATRICIA PINTOR; PRANDO, ERIKA DA COSTA; AUGUSTO MOYANO MUNOZ, JUAN JOSE; ROFFE, MARTIN; MAROSO HAJJ, GLAUCIA NOELI; KOWALSKI, LUIZ PAULO; RAINHO, CLAUDIA APARECIDA; et al. PHF21B as a candidate tumor suppressor gene in head and neck squamous cell carcinomas. MOLECULAR ONCOLOGY, v. 9, n. 2, p. 450-462, FEB 2015. (08/57887-9, 12/04370-4)