Th2 immune responses as a risk factor for focal segmental glomerulosclerosis

• Grant number: 12/04692-1
• Support Opportunities: Regular Research Grants
• Start date: June 01, 2012
• End date: November 30, 2014
• Field of knowledge: Biological Sciences - Immunology - Cellular Immunology
• Principal Investigator: Alexandre de Castro Keller
• Grantee: Alexandre de Castro Keller
• Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil

Abstract

The focal and segmental glomerulosclerosis (FSGS) is a leader cause in the development of chronic kidney disease. The immunological mechanisms involved in the pathogenesis of FSGS are not fully understood, but a growing body of evidence demonstrates an association between a Th2-like profile, characteristic of allergic responses, and disease development.Taken advantage of an adriamycin-induced GESF model, we showed that the Th1/Th2 balance modulates disease development, supporting the relation Th2/GESF. Preliminary data put in evidence an association between disease pathogenesis and increased expression, in renal tissue, of mRNA for IL-33, a cytokine associated with different Th2-mediated pathologies and recently related with acute renal injury. Moreover, deficiency in the IL-33 receptor, ST2, protected mice from adriamycin-induced nephropathy, indicating a role for IL-33 in GESF pathogenesis.Therefore, the aims of this project are to determine the influence of allergic diseases, as asthma, in FSGS susceptibility and severity and establish the role of the IL-33/ST2 axis in disease development. Thus, we intend to determine if allergic asthma constitutes a risk factor for FSGS pathogenesis and the implication of IL-33/ST2 axis in this phenomenon. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

NUNES, JETHE O. F.; APOSTOLICO, JULIANA DE SOUZA; ANDRADE, DAVID A. G.; RUIZ, FRANCIELI S.; FERNANDES, EDGAR R.; ANDERSEN, MONICA L.; KELLER, ALEXANDRE C.; ROSA, DANIELA S.. Sleep deprivation predisposes allergic mice to neutrophilic lung inflammation. Journal of Allergy and Clinical Immunology, v. 141, n. 3, p. 1018+, MAR 2018. (12/04692-1, 14/15061-8)

NOGUEIRA-NETO, JOES; LOURES, FLAVIO V.; SCHANOSKI, ALESSANDRA S.; ANDRADE, DAVID A. G.; GONZATTI, MICHELANGELO B.; COSTA, TANIA A.; VIVANCO, BRUNO C.; XANDER, PATRICIA; ROSA, DANIELA S.; CALICH, VERA L. G.; et al. Invariant Natural Killer T Cells as Key Players in Host Resistance against Paracoccidioides brasiliensis. JOURNAL OF IMMUNOLOGY RESEARCH, v. 2021, APR 16 2021. (16/02189-1, 16/23189-0, 12/04692-1, 11/51258-2)