| Grant number: | 12/04692-1 |
| Support Opportunities: | Regular Research Grants |
| Start date: | June 01, 2012 |
| End date: | November 30, 2014 |
| Field of knowledge: | Biological Sciences - Immunology - Cellular Immunology |
| Principal Investigator: | Alexandre de Castro Keller |
| Grantee: | Alexandre de Castro Keller |
| Host Institution: | Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil |
| City of the host institution: | São Paulo |
Abstract
The focal and segmental glomerulosclerosis (FSGS) is a leader cause in the development of chronic kidney disease. The immunological mechanisms involved in the pathogenesis of FSGS are not fully understood, but a growing body of evidence demonstrates an association between a Th2-like profile, characteristic of allergic responses, and disease development.Taken advantage of an adriamycin-induced GESF model, we showed that the Th1/Th2 balance modulates disease development, supporting the relation Th2/GESF. Preliminary data put in evidence an association between disease pathogenesis and increased expression, in renal tissue, of mRNA for IL-33, a cytokine associated with different Th2-mediated pathologies and recently related with acute renal injury. Moreover, deficiency in the IL-33 receptor, ST2, protected mice from adriamycin-induced nephropathy, indicating a role for IL-33 in GESF pathogenesis.Therefore, the aims of this project are to determine the influence of allergic diseases, as asthma, in FSGS susceptibility and severity and establish the role of the IL-33/ST2 axis in disease development. Thus, we intend to determine if allergic asthma constitutes a risk factor for FSGS pathogenesis and the implication of IL-33/ST2 axis in this phenomenon. (AU)
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