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Colloidal magnetic nanocrystals: synthesis of self-assembled and macromolecules-functionalised nanospheres, nanowires, and nanorods for advanced magnetic recording, biotechnological, and biomedical applications

Grant number: 07/07919-9
Support Opportunities:Research Grants - Young Investigators Grants
Duration: August 01, 2008 - September 30, 2012
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Physical-Chemistry
Principal Investigator:Laudemir Carlos Varanda
Grantee:Laudemir Carlos Varanda
Host Institution: Instituto de Química de São Carlos (IQSC). Universidade de São Paulo (USP). São Carlos , SP, Brazil
Associated scholarship(s):12/02093-3 - Synthesis of Co@Au (superparamagnetics) and CdSe@Zn (quantum dots) core@shell nanostructures for applications as antineoplasia agents, BP.DR
11/16248-6 - Self-organizing of spherical MnO and multipods FePt and CoPt nanoparticles in superlattice-type membranes for ultrahigh density magnetic recording, BP.MS
11/12210-4 - Synthesis and characterization of core-shell superparamagnetic nanomaterials for catalysis and biomedical applications., BP.DR
+ associated scholarships 11/06556-5 - Synthesis and self-assembling of metallic ferromagnetic nanoparticles for ultrahigh density magnetic recording and high-performance permanent magnets applications., BP.DR
11/05022-7 - Surface engeenering of magnetic nanoparticles for biomedicine: coatings with macromolecules in order to stabilize and compatibility in physiological environment, BP.MS
10/04208-7 - Magnetic nanoparticles of gold-coated cobalt and cobalt ferrite as biocompatible materials for biomedical applications, BP.MS
08/07568-4 - FePt-based magnetic nanorods: synthesis, characterization, and self-assembling for ultrahigh-density magnetic recording application., BP.MS
08/08791-9 - Iron oxide-coated metallic magnetic nanoparticles: improvement of the nanoparticle magnetic properties and functionalization for biomedical applications., BP.MS - associated scholarships


In the last years, the reached nanoscience highlight and their rational applications in the synthesis of new technological materials is due, in a great part, to achieved progress in the chemistry and physics areas into nanoscale materials preparation, as well as, from the multidisciplinary efforts involving other knowledge areas such as biochemistry, molecular biology, and medicine. In this context, there have been much attention placed on the magnetic nanoparticles by their insertion in the high-technology and strategic areas such as biomedicine and information storage. The nanotechnology advancements allied to health area it can turn in significant improvement, when the attainment is pointing out of nanomagnetic biosensors, which can be applied in the analysis, security and control of foods, detection of specific substances, environmental control and biomedical applications. In the later, can be emphasizing the tracking and mapping of the specific human body areas by using magnetic resonance imaging, controlled drugs delivery, cancer treatments by hyperthermia and radiotherapy, cell separation, and tissue repair applications. Additionally, the interest in magnetic nanoparticles with high magnetocrystalline anisotropy have been increased due to real potential in the ultra-high magnetic density recording applications, in which some tens Tbits/in2 values are expected to reach in the next decades. According to the relevance and originality of the proposed subject, the aim of the research project is the accomplishment and posterior consolidation of a research line into magnetic colloidal systems in the Physical-Chemistry Department of the Instituto de Química de São Carlos-USP, due to recent appointment of the candidate on RDIDP regime and to area of 40 m2 received for this purpose. In this way, the specific objectives of this project can be summarized as follow: developing new synthetic routes to prepare metallic and oxide magnetic nanoparticles in a monodisperse system and required size, shape (nanospheres, nanowires, and nanorods), magnetic properties and tailored surface adequate for advanced magnetic recording, biotechnological, and biomedical applications. For storage applications, self-assembled and nanostructured nanowires and nanorods shaped materials with high magnetocrystalline anisotropy into two and three dimensions are expected to be obtained in order to provide perpendicular magnetic recording in ultra-high density systems with minimum magnetic coupling and enhanced magnetic alignment. On the other hand, for biomedical applications, spherical nanoparticles with adequate size and magnetic properties will be functionalized with natural and synthetic macromolecules in order to provide biocompatibility in many different systems. Additionally, the surface modifiers can be either totally or partially changed using synthetic procedures in order to introduce a specific group and provide different molecular interactions and applications, such as drugs delivery, selective biosensors for magnetic resonance imaging analysis and hyperthermia treatment, among others. The project theme is enclosed in the technological and strategic frontiers in the world. Thus, expressive and innovative results are strongly expected, which could be used in the national and international patents generation, besides qualified human resources formation to acting in the national nanotechnological subjects, contributing to national technology and nanotechnology development. (AU)

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Scientific publications (10)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
NEVES, HERBERT R.; BINI, RAFAEL A.; BARBOSA, JEAM H. O.; SALMON, CARLOS E. G.; VARANDA, LAUDEMIR C.. Dextran-Coated Antiferromagnetic MnO Nanoparticles for a T-1-MRI Contrast Agent with High Colloidal Stability. PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION, v. 33, n. 3, p. 167-176, . (13/01284-2, 07/07919-9)
BINI, RAFAEL A.; SILVA, MONICA F.; VARANDA, LAUDEMIR C.; DA SILVA, MARCELO A.; DREISS, CECILE A.. Soft nanocomposites of gelatin and poly(3-hydroxybutyrate) nanoparticles for dual drug release. COLLOIDS AND SURFACES B-BIOINTERFACES, v. 157, p. 191-198, . (13/01284-2, 07/07919-9)
SOUZA, C. G. S.; BECK, JR., W.; VARANDA, L. C.. Multifunctional luminomagnetic FePt@Fe3O4/SiO2/Rhodamine B/SiO2 nanoparticles with high magnetic emanation for biomedical applications. JOURNAL OF NANOPARTICLE RESEARCH, v. 15, n. 4, . (07/07919-9)
DA SILVA, TIAGO LUIS; VARANDA, LAUDEMIR CARLOS. Perpendicularly self-oriented and shape-controlled L1(0)-FePt nanorods directly synthesized by a temperature-modulated process. NANO RESEARCH, v. 4, n. 7, p. 666-674, . (08/07568-4, 07/07919-9)
BECK, JR., WATSON; SOUZA, CAIO G. S.; SILVA, TIAGO L.; JAFELICCI, JR., MIGUEL; VARANDA, LAUDEMIR C.. Formation Mechanism via a Heterocoagulation Approach of FePt Nanoparticles Using the Modified Polyol Process. Journal of Physical Chemistry C, v. 115, n. 21, p. 10475-10482, . (08/07568-4, 07/07919-9, 08/08791-9)
SECCO DE SOUZA, CAIO GUILHERME; SOUZA, JOAO BATISTA, JR.; BECK, WATSON, JR.; VARANDA, LAUDEMIR CARLOS. Luminomagnetic Silica-Coated Heterodimers of Core/Shell FePt/Fe3O4 and CdSe Quantum Dots as Potential Biomedical Sensor. Journal of Nanomaterials, v. 2017, p. 9-pg., . (13/01284-2, 12/02093-3, 07/07919-9)
BINI, RAFAEL A.; MORAES, DANIEL A.; VARANDA, LAUDEMIR C.. Preparation of Poly(3-hydroxybutyrate) Micro- and Nanoparticles as Hydrophobic Drugs Carrier Using Self-emulsifying Nanoemulsion Method. BRITISH JOURNAL OF PHARMACEUTICAL RESEARCH, v. 12, n. 6, . (13/01284-2, 07/07919-9)
SECCO DE SOUZA, CAIO GUILHERME; SOUZA, JR., JOAO BATISTA; BECK, JR., WATSON; VARANDA, LAUDEMIR CARLOS. Luminomagnetic Silica-Coated Heterodimers of Core/Shell FePt/Fe3O4 and CdSe Quantum Dots as Potential Biomedical Sensor. Journal of Nanomaterials, . (12/02093-3, 13/01284-2, 07/07919-9)
SOUZA, JR., JOAO B.; VARANDA, LAUDEMIR C.. Magneto-plasmonic Au-Coated Co nanoparticles synthesized via hot-injection method. Nanotechnology, v. 29, n. 6, . (10/04208-7, 12/02093-3, 13/01284-2, 07/07919-9)

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