Abstract
In the last years, the reached nanoscience highlight and their rational applications in the synthesis of new technological materials is due, in a great part, to achieved progress in the chemistry and physics areas into nanoscale materials preparation, as well as, from the multidisciplinary efforts involving other knowledge areas such as biochemistry, molecular biology, and medicine. In this context, there have been much attention placed on the magnetic nanoparticles by their insertion in the high-technology and strategic areas such as biomedicine and information storage. The nanotechnology advancements allied to health area it can turn in significant improvement, when the attainment is pointing out of nanomagnetic biosensors, which can be applied in the analysis, security and control of foods, detection of specific substances, environmental control and biomedical applications. In the later, can be emphasizing the tracking and mapping of the specific human body areas by using magnetic resonance imaging, controlled drugs delivery, cancer treatments by hyperthermia and radiotherapy, cell separation, and tissue repair applications. Additionally, the interest in magnetic nanoparticles with high magnetocrystalline anisotropy have been increased due to real potential in the ultra-high magnetic density recording applications, in which some tens Tbits/in2 values are expected to reach in the next decades. According to the relevance and originality of the proposed subject, the aim of the research project is the accomplishment and posterior consolidation of a research line into magnetic colloidal systems in the Physical-Chemistry Department of the Instituto de Química de São Carlos-USP, due to recent appointment of the candidate on RDIDP regime and to area of 40 m2 received for this purpose. In this way, the specific objectives of this project can be summarized as follow: developing new synthetic routes to prepare metallic and oxide magnetic nanoparticles in a monodisperse system and required size, shape (nanospheres, nanowires, and nanorods), magnetic properties and tailored surface adequate for advanced magnetic recording, biotechnological, and biomedical applications. For storage applications, self-assembled and nanostructured nanowires and nanorods shaped materials with high magnetocrystalline anisotropy into two and three dimensions are expected to be obtained in order to provide perpendicular magnetic recording in ultra-high density systems with minimum magnetic coupling and enhanced magnetic alignment. On the other hand, for biomedical applications, spherical nanoparticles with adequate size and magnetic properties will be functionalized with natural and synthetic macromolecules in order to provide biocompatibility in many different systems. Additionally, the surface modifiers can be either totally or partially changed using synthetic procedures in order to introduce a specific group and provide different molecular interactions and applications, such as drugs delivery, selective biosensors for magnetic resonance imaging analysis and hyperthermia treatment, among others. The project theme is enclosed in the technological and strategic frontiers in the world. Thus, expressive and innovative results are strongly expected, which could be used in the national and international patents generation, besides qualified human resources formation to acting in the national nanotechnological subjects, contributing to national technology and nanotechnology development. (AU)
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