Mechanisms involved in increased risk of bleeding in patients with prior stroke or transient ischemic attack in use of aspirin

• Grant number: 12/04930-0
• Support Opportunities: Regular Research Grants
• Start date: August 01, 2012
• End date: July 31, 2014
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: José Carlos Nicolau
• Grantee: José Carlos Nicolau
• Host Institution: Instituto do Coração Professor Euryclides de Jesus Zerbini (INCOR). Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
• Associated researchers: Renata de Souza Barreiros

Abstract

Study population: 100 patients with prior Ischemic Stroke or Transient Ischemic Attack, previous hospitalization due to Acute Coronary Syndrome (unstable angina, non-ST elevation or ST-elevation myocardial infarction), current use of ASA. Exclusion Criteria: Previously known hemorrhagic stroke; use of another antiplatelet agent than ASA; use of NSAIDs and / or dipyridamole; known platelet dysfunction or platelets <150.000/¼L or > 450. 000/¼L; GFR (MDRD) <30 mL / min, in the last 6 months; terminal illness; liver disease or coagulation disorder; refuse to participate in the study. (AU)