Pulmonary and cardiovascular alterations induced by inhalation of concentrated particulate material from the atmosphere of São Paulo

• Grant number: 02/09804-0
• Support Opportunities: Regular Research Grants
• Start date: January 01, 2005
• End date: May 31, 2009
• Field of knowledge: Health Sciences - Medicine
• Principal Investigator: Paulo Hilário Nascimento Saldiva
• Grantee: Paulo Hilário Nascimento Saldiva
• Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

The determination of the toxic potential of inhalable particulate material (PM2.5) is not totally determined, especially when one is working with particles derived from the “real world”. Clarification of this point is of primordial importance when seeking to determine the mechanisms through which PM2.5 causes increases in morbidity and mortality in the exposed populations, as pointed out in the epidemiological studies. The general objective of this study will be to determine the toxicity of different doses of PM2.5.We will evaluate an extensive battery of histopathological, hematological and cardiovascular tests in mice exposed to the ambient particle concentrator (CPA) in São Paulo. By means of the variation in the profile of the emitting sources, it is hoped that the present project may contribute to the question of pulmonary and cardiovascular toxicity of the different constituent elements of PM2.5. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DAVEL, ANA PAULA; LEMOS, MIRIAM; PASTRO, LUCIANA MANFRE; PEDRO, SIBELLI COSME; DE ANDRE, PAULO AFONSO; HEBEDA, CRISTINA; FARSKY, SANDRA HELENA; SALDIVA, PAULO HILARIO; ROSSONI, LUCIANA VENTURINI. Endothelial dysfunction in the pulmonary artery induced by concentrated fine particulate matter exposure is associated with local but not systemic inflammation. Toxicology, v. 295, n. 1-3, p. 39-46, MAY 16 2012. (02/09804-0)

Filed patent(s) as a result of this research project