Implementation of ultrafast 2D NMR spectroscopy in LC-SPE-NMR equipment

• Grant number: 11/01949-9
• Support Opportunities: Research Grants - Visiting Researcher Grant - International
• Start date: April 24, 2011
• End date: May 01, 2011
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Antonio Gilberto Ferreira
• Grantee: Antonio Gilberto Ferreira
• Visiting researcher: Patrick Giraudeau
• Visiting researcher institution: Université de Nantes, France
• Host Institution: Centro de Ciências Exatas e de Tecnologia (CCET). Universidade Federal de São Carlos (UFSCAR). São Carlos , SP, Brazil

Abstract

The technique of Nuclear Magnetic Resonance (NMR) known as ultra-fast-NMR has been developed in recent years by Professor. Lucio Frydman and colleagues, in which full-NMR spectra as gCOSY, gHSQC and gHMBC have been proposed to be obtained with a total experiment time in a fraction of seconds when in a conventional approach it would take hours. However, the understanding and implementation of this approach are not routine and much less trivial and so far no manufacturers companies of NMR equipments have been implemented this methodology yet. So, we are still in an experimental phase. Moreover this method requires equipment with scanning time domain much faster that the old fashion one like as we have in our lab. For this reason, the coming of Prof. Patrick Giraudeau, from University of Nantes-France, one of the collaborators of Prof. Lucio Frydman, will be extremely valuable to our lab. One of our PhD students has stayed in his lab. learning the rudiments of this technique and provided to begin its implementation into our equipment. However, the proposed work to be developed by Prof. Giraudeau, in our lab., will be the implementation of this methodology but for experiments using the hyphenation techniques know as LC-SPE-NMR, in our recently acquired 14.1 T NMR equipment. The LC-SPE-NMR is already quite widespread overseas, but until the present, it is not used whit the technique ultrafast-NMR for detection. It is important to emphasize that the success of these project can will provide not only an enormous reduction machine time, but mainly, the possibility of monitoring dynamic events and/or reactions in "real time". Moreover, the collaborations of the two laboratories will allow the possibility of sharing knowledge and developing work together through the PhD student in the "Sandwich" program, scientific visits, publications, etc. between the two institutions. (AU)