Studies of interactions between copper complexes with antitumor activity and proteins kinases and topoisomerases

• Grant number: 12/03080-2
• Support Opportunities: Research Grants - Visiting Researcher Grant - International
• Start date: August 01, 2012
• End date: August 31, 2012
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Inorganic Chemistry
• Principal Investigator: Ana Maria da Costa Ferreira
• Grantee: Ana Maria da Costa Ferreira
• Visiting researcher: Alessandro Desideri
• Visiting researcher institution: Università degli Studi di Roma Tor Vergata, Italy
• Host Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

The programmed activities for Prof. Desideri during his stay with us includes participation in many of ours planning of new experiments to study metal-complexes and biomolecules interactions (DNA and proteins), discussion of results, active involvement in our Seminars, that occur weekly, and participation in the discipline QFL 5801 Copper Proteins and Metabolism of Copper, that I will offer at IQ-USP to graduate students in the period August to October, 2012. Prof. Desideri will give classes in August, mainly about spectroscopy of copper proteins. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

CASTELLI, SILVIA; GONCALVES, MARCOS BROWN; KATKAR, PRAFULLA; STUCHI, GABRIELA CRISTINA; ALVES COUTO, RICARDO ALEXANDRE; PETRILLI, HELENA MARIA; DA COSTA FERREIRA, ANA MARIA. Comparative studies of oxindolimine-metal complexes as inhibitors of human DNA topoisomerase IB. Journal of Inorganic Biochemistry, v. 186, p. 85-94, SEP 2018. (11/50318-1, 12/03080-2, 13/07937-8)

KATKAR, PRAFULLA; COLETTA, ANDREA; CASTELLI, SILVIA; SABINO, GUSTAVO L.; ALVES COUTO, RICARDO A.; DA COSTA FERREIRA, ANA M.; DESIDERI, ALESSANDRO. Effect of oxindolimine copper(II) and zinc(II) complexes on human topoisomerase I activity. METALLOMICS, v. 6, n. 1, p. 117-125, 2014. (11/50318-1, 12/03080-2)