Lung function tests and asthma diagnosis in common variable immunodeficiency

• Grant number: 08/05750-0
• Support Opportunities: Regular Research Grants
• Start date: December 01, 2008
• End date: November 30, 2010
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Pedro Francisco Giavina-Bianchi Junior
• Grantee: Pedro Francisco Giavina-Bianchi Junior
• Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Obstructive diseases, as asthma, chronic obstructive pulmonary disease and bronchiectasis, are present in approximately 50 % of patients with common variable immunodeficiency (CIVD). Alergic asthma diagnosis in patients with CVID is difficult. Objective: The objectives of this study are: 1) evaluation of pulmonary function in patients with CIVD, based on following parameters: spirometry, brochial provocation with histamine and bronchial provocation with allergen; 2) investigate asthma diagnosis in patients with CVID; 3) perform investigation on the role of IgE as a trigger of asthma in patients with CVID. Methods: This work will study sixty-two patients with CVID. Patients' clinical history will be record, and they will be submitted to prick test, total and specific serum IgE measurement, spirometry, specific (Der p) and non-specific bronchial challenge. A comparison will be performed in the bronchial challenge results of the group suggestive for allergic asthma and the patients without allergic asthma. (AU)