Functional ethological investigations into the role of discrete regions of the lateral hypothalamic area implicated by their neuronal connections in the control of defensive behaviors

• Grant number: 12/50517-7
• Support type: Regular Research Grants
• Duration: September 01, 2012 - August 31, 2013
• Field of knowledge: Biological Sciences - Physiology - Physiology of Organs and Systems
• Cooperation agreement: University of Southern California
• Principal researcher: Newton Sabino Canteras
• Grantee: Newton Sabino Canteras
• Principal researcher abroad: Joel David Hahn
• Institution abroad: University of Southern California (USC), United States
• Home Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated research grant: 11/02425-3 - The role of the dorsal premammillary nucleus and its main targets in the neuroendocrine and behavioral responses observed after social defeat, AP.R

Abstract

The hypothalamus has a central role in the control of fundamental goal-oriented behaviors, but a clear understanding of its structure-function relations remains incomplete. The gaps in our knowledge are particularly evident for the poorly studied lateral hypothalamic area (LHA). However, a series of recent tract-tracing studies have made substantial inroads in to this relatively unstudied part of the brain REFS. In parallel with new structural knowledge, a series of functional studies have sought to characterize hypothalamic circuitry related to defensive behaviors (REFS); the latter have shown that discrete, highly interconnected hypothalamic, regions are involved in stereotyped defensive responses. Moreover, the connections of discrete LHA regions indicate they too may participate in defensive responses. Experiments will be carried out to investigate the possible contribution of recently characterized LHA regions to defensive responses involving other hypothalamic (and extra hypothalamic) regions shown to be involved in defensive responses, and with which they are connected. Discrete chemical lesions will be made in LHA regions of interest, to be followed by behavioral testing using an ethological approach with two models of defensive behavior: 1) resident-intruder, and 2) predator defense. In sum, the project will build on recent and ongoing work by both principle investigators and their colleagues into hypothalamic structure and function. (AU)