Scientific cooperation for the study of haemoglobinopathies: clinical, cellular and molecular alterations

• Grant number: 12/50582-3
• Support Opportunities: Regular Research Grants
• Start date: October 01, 2012
• End date: September 30, 2014
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Agreement: King's College London
• Principal Investigator: Nicola Amanda Conran Zorzetto
• Grantee: Nicola Amanda Conran Zorzetto
• Principal researcher abroad: Swee Lay Thein
• Institution abroad: King's College London, England
• Host Institution: Centro de Hematologia e Hemoterapia (HEMOCENTRO). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated research grant: 08/57441-0 - Clinical, cellular and molecular alterations in hemoglobinopathies and other hereditary hemolytic anemias, AP.TEM

Abstract

The inherited disorders of haemoglobin are the most prevalent monogenic disorders of mankind. Over recent decades, there has been significant progress in the elucidation of the molecular pathology of the diverse disturbances related to this protein, resulting in an enormous advance in the control and treatment of the diseases caused by these alterations. Results derived from studies of these alterations have been of great importance to our present understanding of several aspects of normal gene structure, function, and regulation. Brazil presents a particular regional heterogeneity in the frequency of the haemoglobinopathies. Over the last twenty years, the Hemoglobinopathies Research Group at the Haematology Centre, UNICAMP, has been regularly studying several aspects of inherited haemoglobin abnormalities in the Brazilian population. The research group headed by Professor Swee Lay Thein, KCL School of Medicine, constitutes, today, the group at the forefront of research, both clinical and experimental, in haemoglobinopathies and the regulation of fetal haemoglobin production in the United Kingdom. As such, a renewal of the official FAPESP-KCL collaboration between the Hemoglobinopathies Research Group, UNICAMP, and Professor Thein, and her team, would continue to provide an opportunity for researchers involved in project FAPESP: 2008/57441-0 to benefit from her team's knowledge and expertise. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

GARRIDO, VANESSA TONIN; SONZOGNI, LAURA; MTATIRO, SIANA NKYA; COSTA, FERNANDO F.; CONRAN, NICOLA; THEIN, SWEE LAY. Association of plasma CD4OL with acute chest syndrome in sickle cell anemia. CYTOKINE, v. 97, p. 104-107, SEP 2017. (08/57441-0, 12/50582-3, 12/22043-0, 11/17553-7)