| Grant number: | 12/50722-0 |
| Support Opportunities: | Regular Research Grants |
| Start date: | October 01, 2012 |
| End date: | September 30, 2014 |
| Field of knowledge: | Health Sciences - Medicine - Medical Radiology |
| Agreement: | King's College London |
| Principal Investigator: | Edson Amaro Junior |
| Grantee: | Edson Amaro Junior |
| Principal researcher abroad: | Thomas White |
| Institution abroad: | King's College London, England |
| Host Institution: | Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil |
| Associated research grant: | 09/53443-1 - Neuroimmunology, functional genomics and neuroimaging: an integrated approach for studying physiopathology and treatment in refractory epilepsy , AP.TEM |
Abstract
Morphometric features of the hemodynamic response function (HRF) potentially provide a window on to alternative characteristics of neuronal activity using fMRI. Recently, neural processing time (NPT) - the period for which event-related neuonal activity occurs - was proposed as a measurable feature of the biophysical model of HRF. However, systematic investigation of the factors modulating NPT has not yet been conducted but could potentially mark a significant improvement of our understanding of the neural conditions characteristic of efficient information processing. Accordingly, we propose a collaborative study which will adapt NPT inference, developed at USP, to test four principal hypotheses on N-back data previously collected at KCL: (i) that NPT in decision-making regions will be modulated by working memory load, being shorter in low memory-load conditions; (ii) that individuals with psychosis will exhibit aberrant NPT on account of diminished cortical efficiency, with psychosis-related differences moderated by symptom profile; (iii) that this aberrance will be mirrored by healthy individuals following amphetamine sensitisation; and (iv) that simultaneously acquired electroencephalography (EEG)-fMRI data collected during working memory performance will provide a means of further validating NPT by permitting the assessment of the relationship between neuroelectric components (from EEG) and fMRI NPT measures. (AU)
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