Structural modification, physical-chemical characterization and biological testing of biomaterials and tissue for ophthalmic use

• Grant number: 12/07343-8
• Support Opportunities: Regular Research Grants
• Start date: November 01, 2012
• End date: April 30, 2015
• Field of knowledge: Health Sciences - Medicine - Surgery
• Principal Investigator: Paulo Schor
• Grantee: Paulo Schor
• Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil
• Associated researchers: Acacio Alves de Souza Lima Filho ; Andreia de Araújo Morandim ; Octaviano Magalhães Junior ; Patrícia Alessandra Bersanetti ; Wallace Chamon Alves de Siqueira

Abstract

In recent decades the application of physical concepts has led to the development of new proposals for diagnosis and treatment of eye diseases and the understanding and integration with the field of chemistry has been one of innovative approaches to propose new eye treatments. In this context, since the cornea to the vitreous humor can be achieved advances and possibilities of structural changes aimed at greater efficiency and security procedures such as vitrectomy and corneal remodeling for example. Thus, the study and control of cross-links between molecules autologous or artificially constructed to form the basis of this project in which we intend to develop methods to produce tissues for replacement and to transforme properties of own tissues by addition of catalysts or structural proteins. After obtaining new compounds will make the determination of their physical and chemical structural properties and also toxicity tests will be performed. The project therefore involves intense integration between ophthalmologists, physicists, chemists and pharmacists and has the potential to integrate college students and profisional in differents areas. It is a multidisciplinary, multicampi and translacional subject, that we believe have ability and resources for development. (AU)

Scientific publications

(5)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DA PAZ, AMANDA C.; BERSANETTI, PATRICIA A.; SALOMAO, MARCELLA Q.; AMBROSIO, JR., RENATO; SCHOR, PAULO. Theoretical Basis, Laboratory Evidence, and Clinical Research of Chemical Surgery of the Cornea: Cross-Linking. JOURNAL OF OPHTHALMOLOGY, 2014. (12/07343-8, 13/20857-3)

MORANDIM-GIANNETTI, ANDREIA DE ARAUJO; SILVA, ROSIANNE CRISTINA; MAGALHAES JUNIOR, OCTAVIANO; SCHOR, PAULO; BERSANETTI, PATRICIA ALESSANDRA. Conditions for obtaining polyvinyl alcohol/trisodium trimetaphosphate hydrogels as vitreous humor substitute. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, v. 104, n. 7, p. 1386-1395, OCT 2016. (12/07343-8)

BERSANETTI, PATRICIA A.; BUENO, TATIANE L. N.; MORANDIM-GIANNETTI, ANDREIA DE A.; NOGUEIRA, REGINA F.; MATOS, JIVALDO R.; SCHOR, PAULO. Characterization of Rabbit Corneas Subjected to Stromal Stiffening by the Acai Extract (Euterpe oleracea). CURRENT EYE RESEARCH, v. 42, n. 4, p. 528-533, APR 2017. (12/07343-8, 13/20857-3)

MORANDIM-GIANNETTI, ANDREIA DE ARAUJO; RUBIO, SAMANTHA REGINA; NOGUEIRA, REGINA FREITAS; ORTEGA, FERNANDO DOS SANTOS; MAGALHAES JUNIOR, OCTAVIANO; SCHOR, PAULO; BERSANETTI, PATRICIA ALESSANDRA. Characterization of PVA/glutaraldehyde hydrogels obtained using Central Composite Rotatable Design (CCRD). JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, v. 106, n. 4, p. 1558-1566, MAY 2018. (12/07343-8)

DA PAZ, AMANDA C.; BERSANETTI, PATRICIA A.; SALOMAO, MARCELLA Q.; AMBROSIO, RENATO, JR.; SCHOR, PAULO. Theoretical Basis, Laboratory Evidence, and Clinical Research of Chemical Surgery of the Cornea: Cross-Linking. JOURNAL OF OPHTHALMOLOGY, v. 2014, p. 9-pg., 2014-01-01. (13/20857-3, 12/07343-8)