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Characterization of corneas after structural modification by agents that promotes collagen crosslinking

Grant number: 13/20857-3
Support type:Regular Research Grants
Duration: February 01, 2014 - July 31, 2016
Field of knowledge:Health Sciences - Medicine
Principal Investigator:Patrícia Alessandra Bersanetti
Grantee:Patrícia Alessandra Bersanetti
Home Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil
Assoc. researchers:Andreia de Araújo Morandim ; Jivaldo do Rosário Matos ; Paulo Schor ; Regina Freitas Nogueira Carlstron ; Wallace Chamon Alves de Siqueira


In recent decades the application of physical and chemical concepts has led to the development of possibilities of structural changes aimed at greater efficiency and security procedures as the remodeling of the cornea. In keratoconus, the cornea acquires a cone shape due to loosening of the collagen fibrils of the stroma. Some treatments useful in correcting refractive errors show no apparent effect on disease progression. A recent methodology which consists of the application of riboflavin photo-stimulated by ultraviolet radiation at 365 nm, after removal of the epithelium to promote covalent bonds in collagen of the cornea, has been effective in blocking disease progression. The increase of the biomechanical strength and resistance of the cornea is provided by the increased in number of crosslinks between collagen fibrils. In this context, the study and control of cross-links between biomolecules are the basis of this study in which it is intended to develop a method of transformation of corneal properties by the addition of exogenous compounds or structural proteins, without the use of ultraviolet radiation. After the structural change, it will make the determination of physical, biochemical and thermodynamic corneal properties. The project therefore enables integration between the clinical and basic sciences, and has the potential to bring together researchers and undergraduate and postgraduate in various areas of knowledge. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ITO DA CRUZ, LUIZ GUILHERME; MORAES, GABRIELA DE ANDRADE; NOGUEIRA, REGINA FREITAS; MORANDIM-GIANNETTI, ANDREIA DE ARAUJO; BERSANETTI, PATRICIA ALESSANDRA. DSC characterization of rabbit corneas treated with Stryphnodendron adstringens (Mart.) Coville extracts. JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY, v. 131, n. 1, p. 621-625, JAN 2018. Web of Science Citations: 2.
BERSANETTI, PATRICIA A.; BUENO, TATIANE L. N.; MORANDIM-GIANNETTI, ANDREIA DE A.; NOGUEIRA, REGINA F.; MATOS, JIVALDO R.; SCHOR, PAULO. Characterization of Rabbit Corneas Subjected to Stromal Stiffening by the Acai Extract (Euterpe oleracea). CURRENT EYE RESEARCH, v. 42, n. 4, p. 528-533, APR 2017. Web of Science Citations: 4.
DA PAZ, AMANDA C.; BERSANETTI, PATRICIA A.; SALOMAO, MARCELLA Q.; AMBROSIO, JR., RENATO; SCHOR, PAULO. Theoretical Basis, Laboratory Evidence, and Clinical Research of Chemical Surgery of the Cornea: Cross-Linking. JOURNAL OF OPHTHALMOLOGY, 2014. Web of Science Citations: 5.

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