| Grant number: | 12/16778-8 |
| Support Opportunities: | Regular Research Grants |
| Start date: | November 01, 2012 |
| End date: | October 31, 2014 |
| Field of knowledge: | Health Sciences - Medicine - Maternal and Child Health |
| Principal Investigator: | Gil Guerra Júnior |
| Grantee: | Gil Guerra Júnior |
| Host Institution: | Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil |
| City of the host institution: | Campinas |
| Associated researchers: | Bruno Geloneze Neto ; Sofia Helena Valente de Lemos-Marini |
Abstract
The deficiency of 21-hydroxylase (D21OH) is the most common form of congenital adrenal hyperplasia (CAH), responsible for more than 90% of cases with its classical form. With the improvement of diagnosis and the introduction of replacement therapy with corticosteroids, there was significant increment in patient survival. However, studies on the long-term effects of this treatment, mainly about cardiometabolic risk, are still rare and partly controversial. Therefore, the aim of this study will be evaluate the cardiometabolic risk, including insulin sensitivity, in patients with the classical form of CAH-D21OH compared to a control group matched for age, sex and BMI. Also we will analyze the association of risk factors present in metabolic syndrome in patients with CAH-21OHD with age, sex, genotype, disease control, body composition, physical activity, serum laboratory parameters (leptin, adiponectin, C-reactive protein, IL-6, Il-1², and metanephrine in urine and serum), insulin resistance, thickness of carotid intima-media (TCIM), and indirect calorimetry. Patients aged over six years, of both sexes, with a diagnosis of HAC-D21H and monitored routinely for at least two years in our clinic, will be evaluated. For the determination of cardiometabolic risk evaluations about body composition (BMI, DXA, skinfold thickness, bioelectrical impedance analysis), blood pressure monitoring for 24 hours, blood parameters (lipid profile, hyperglycemic clamp, leptin, adiponectin, C-reactive protein and free metanephrine), physical activity by questionnaire, and TCIM by ultrasonography will take place. In the analysis of results, statistical tests (chi-square, Student's t and Mann-Whitney test, and multiple linear regression) with p less than 0.05 (AU)
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