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Therapeutic effectiveness of the physical exercise adjunctive to pharmacotherapy in major depression associated with biomarkers


Depression is a disorder that causes major harm to physical health and social life. It induces isolation, reduced physical and work capacity and increasing the risk of death. In contrast, exercise helps to maintain quality of life, also inducing improvement of cognitive functions, stimulation of brain plasticity and resilience, in addition to promoting self-esteem and social interaction. The precise mechanisms by which exercise improves symptoms of depression are not fully clear, but it is probably multifactorial. In this project, we aim to investigate variables that provide additional information about biomarkers involved in the pathophysiology of depression and therapeutic response to exercise. We expect to find changes in biomarkers associated with potential mechanisms of neuroprotection (cytokines, markers of oxidative stress, BDNF, cortisol) after exercise program and the role in the therapeutics of depression. To evaluate functional assessment indices will be used ergospirometry, a test that determines the respiratory, cardiovascular and metabolic activity.Overall, this project will help to investigate alternative adjunctive treatments for depression and their associated biomarkers with response. (AU)

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(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SIQUEIRA, CRISTIANA CARVALHO; VALIENGO, LEANDRO L.; CARVALHO, ANDRE F.; SANTOS-SILVA, PAULO ROBERTO; MISSIO, GIOVANI; DE SOUSA, RAFAEL T.; DI NATALE, GEORGIA; GATTAZ, WAGNER F.; MORENO, RICARDO ALBERTO; MACHADO-VIEIRA, RODRIGO. Antidepressant Efficacy of Adjunctive Aerobic Activity and Associated Biomarkers in Major Depression: A 4-Week, Randomized, Single-Blind, Controlled Clinical Trial. PLoS One, v. 11, n. 5 MAY 6 2016. Web of Science Citations: 10.

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