Heterotypic culture: the cross-talking between epithelial tumor cells, mammary stroma, macrophages and platelets in breast cancer: the release of proteolytic enzymes and signaling of toll-like receptors

• Grant number: 12/19780-3
• Support Opportunities: Regular Research Grants
• Start date: December 01, 2012
• End date: May 31, 2015
• Field of knowledge: Health Sciences - Medicine - Maternal and Child Health
• Principal Investigator: Manoel João Batista Castello Girão
• Grantee: Manoel João Batista Castello Girão
• Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil

Abstract

In breast cancer, stromal cells include resident adipocyte and fibroblast, a wide range of recruited hematopoietic cells, and newly formed blood vessels qith their associated cells. Dynamic and reciprocal communication between epithelial and stromal compartments occurs during breast cancer progression. (AU)

Scientific publications

(4)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

OTTAIANO, TATIANA F.; ANDRADE, SHEILA S.; DE OLIVEIRA, CLEIDE; SILVA, MARIANA C. C.; BURI, MARCUS V.; JULIANO, MARIA A.; GIRAO, MANOEL J. B. C.; SAMPAIO, MISAKO U.; SCHMAIER, ALVIN H.; WLODAWER, ALEXANDER; et al. Plasma kallikrein enhances platelet aggregation response by subthreshold doses of ADP. Biochimie, v. 135, p. 72-81, APR 2017. (12/19780-3, 09/53766-5)

BONAZZA, CAMILA; ANDRADE, SHEILA SIQUEIRA; SUMIKAWA, JOANA TOMOMI; BATISTA, FABRICIO PEREIRA; PAREDES-GAMERO, EDGAR J.; GIRAO, MANOEL J. B. C.; OLIVA, MARIA LUIZA V.; CASTRO, RODRIGO AQUINO. Primary Human Uterine Leiomyoma Cell Culture Quality Control: Some Properties of Myometrial Cells Cultured under Serum Deprivation Conditions in the Presence of Ovarian Steroids. PLoS One, v. 11, n. 7, JUL 8 2016. (12/19851-8, 09/53766-5, 12/19780-3)

ANDRADE, SHEILA SIQUEIRA; SUMIKAWA, JOANA TOMOMI; CASTRO, ELOISA DOGNANI; BATISTA, FABRICIO PEREIRA; PAREDES-GAMERO, EDGAR; OLIVEIRA, LILIAN CAROLINA; GUERRA, IZABEL MONASTERIO; PERES, GIOVANI BRAVIN; CAVALHEIRO, RENAN PELLUZZI; JULIANO, LUIZ; et al. Interface between breast cancer cells and the tumor microenvironment using platelet-rich plasma to promote tumor angiogenesis - influence of platelets and fibrin bundles on the behavior of breast tumor cells. ONCOTARGET, v. 8, n. 10, p. 16851-16874, 2017. (12/19851-8, 09/53766-5, 12/19780-3)

ANDRADE, SHEILA SIQUEIRA; GOUVEA, IURI ESTRADA; SILVA, MARIANA CRISTINA C.; CASTRO, ELOISA DOGNANI; DE PAULA, CLAUDIA A. A.; OKAMOTO, DEBORA; OLIVEIRA, LILIAN; PERES, GIOVANI BRAVIN; OTTAIANO, TATIANA; FACINA, GIL; et al. Cathepsin K induces platelet dysfunction and affects cell signaling in breast cancer - molecularly distinct behavior of cathepsin K in breast cancer. BMC CANCER, v. 16, MAR 1 2016. (12/19851-8, 09/53766-5, 12/19780-3)