Role of Fc receptors in bacterial immune evasion

• Grant number: 12/51468-0
• Support Opportunities: Research Projects - Thematic Grants
• Start date: February 01, 2013
• End date: January 31, 2016
• Field of knowledge: Biological Sciences - Immunology
• Agreement: ANR - Blanc
• Principal Investigator: Irineu Tadeu Velasco
• Grantee: Irineu Tadeu Velasco
• Principal researcher abroad: Renato Monteiro
• Institution abroad: Université Paris Diderot - Paris 7, France
• Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

The goal of this project will be to : 1) Characterize the interaction between S. pneumonia and CD89 and analyze its role in vivo in the bacterial invasion through activation of ITAMi signaling using CD89 transgenic models. The role of C reactive protein, a new CD89 ligand, will be also analyzed. 2) Identify bacterial partners of CD16 and CD89 using phage display techniques. We will initially characterize the tridimensional CD16 and E. coli interaction site and investigate if similar approach can be used to elucidate inhibitory signals by different bacteria, such as those following S. pneumonia interaction with the CD89 receptor. 3) Develop new therapeutic tools for sepsis through different blockade approaches of bacterial-receptor interaction and/or ITAMi pathway. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

BEPPLER, JAQUELINE; KOEHLER-SANTOS, PATRICIA; PASQUALIM, GABRIELA; MATTE, URSULA; ALHO, CLARICE SAMPAIO; DIAS, FERNANDO SUPARREGUI; KOWALSKI, THAYNE WOYCINCK; VELASCO, IRINEU TADEU; MONTEIRO, RENATO C.; DA SILVA, FABIANO PINHEIRO. Fc Gamma Receptor IIA (CD32A) R131 Polymorphism as a Marker of Genetic Susceptibility to Sepsis. Inflammation, v. 39, n. 2, p. 518-525, APR 2016. (12/51468-0)

Filed patent(s) as a result of this research project