Association of genetic factor and risk for preterm delivery in women with cervical insufficiency

• Grant number: 12/24920-9
• Support Opportunities: Regular Research Grants
• Duration: April 01, 2013 - March 31, 2016
• Field of knowledge: Health Sciences - Medicine - Maternal and Child Health
• Principal Investigator: Mario Henrique Burlacchini de Carvalho
• Grantee: Mario Henrique Burlacchini de Carvalho
• Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated researchers: Ana Paula Vieira Dias Alves ; José Eduardo Levi ; Marcelo Zugaib ; Renata Moscolini Romão ; Rossana Pulcineli Vieira Francisco

Abstract

Prematurity is the leading cause of morbidity and mortality worldwide and among the risk factors for preterm birth, cervical incompetence is a major risk. Currently, we observe genetic component in the occurrence of prematurity. Among the genetic factors, single nucleotide polymorphisms (SNPs) of some genes studied among many, are associated with the occurrence of preterm birth. Recent studies report that SNPs in genes associated with collagen, the extracellular matrix and production of interleukins is directly related to the length of the cervix. Thus, these SNPs were associated with prematurity associated with premature cervical shortening. These SNPs are located in genes A1 COL 1, COL4A3, TGF-G, TIMP2 and IL6-R described in several recent studies, were selected for this project. The target population of the research, are patients with a history of cervical incompetence with the goal of developing diagnostic aids in the diagnosis of cervical incompetence, which is still largely clinical and assess the risk of preterm birth in women undergoing uterine cerclage when carrier polymorphism (s) conferring increased risk. The expected result would be the identification of new genetic markers that would facilitate the screening of women with a history of miscarriages, premature births and those whose treatment decision depends on that obstetric history. The contribution of new markers, it also seeks to reduce the rates of prematurity, the possibility of better assistance to these women. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

ALVES, ANA PAULA V. D.; FREITAS, AMANDA B.; LEVI, JOSE EDUARDO; AMORIM FILHO, ANTONIO G.; FRANCO, LUCAS A. M.; HOSHIDA, MARA SANDRA; PATINO, ELIZABETH G.; FRANCISCO, V, ROSSANA P.; CARVALHO, MARIO HENRIQUE B.. COL1A1, COL4A3, TIMP2 and TGFB1 polymorphisms in cervical insufficiency. JOURNAL OF PERINATAL MEDICINE, v. 49, n. 5, p. 553-558, 2021. (12/24920-9)