The effect of exercise on hemarthrosis in haemophiliac a mice (Knockout FVIII)

• Grant number: 12/18588-1
• Support Opportunities: Regular Research Grants
• Start date: May 01, 2013
• End date: April 30, 2016
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Suzana Beatriz Verissimo de Mello
• Grantee: Suzana Beatriz Verissimo de Mello
• Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Haemophiliac arthropathy is the main complication in Hemophilia and occur as a result of repetitive bleedings in the joint space. This condition lead to severe functional limitations and to a poor quality of life. Inflammatory changes in synovial membrane and degenerative alteration in cartilage drive this condition in the joints. The process of cleaning the joint space after a bleeding results in a hemosiderin deposition in the synovial membrane which in turn, stimulate the proliferation, hipertrophic and neovascularization. After developed a chronic synovits the synovial membrane produce and release inflammatory mediators as IL-1beta, TNF-alpha, oxigen reactive species that induce a degenerative process in cartilage.Usually, the treatment after a joint bleeding involves the reposition of the coagulation factor, rest, ice and elevation of the affected limb, but sometimes others conducts as the punction of the blood in the joint space, infiltration of anesthesic and anti-inflammatory substances are needed. The therapeutic exercises are widely recommended for the patients with hemophilia with the objective of prevent joint deformit, increase muscle force and to improve the functional capacity. But unlike the several studies showing the benefits of exercise in degenerative (osteoarthrosis) and inflammatory (rheumatoid arthritis) joint disease, we still don´t know the effects of exercise after a joint bleeding in haemophilic population. So, the objective of this study is to evaluate the effect of exercise (swimming) after an haemarthrosis and on chronic sinovits iin haemophilic A mice (knockout FVIII). (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

SOUZA, F.; ROQUE, F.; OLIVEIRA, E.; PICOLLO, G.; CURY, Y.; TANAKA, C.; MELLO, S. B.. SWIMMING EXERCISE CAN ALTER THE PATTERN OF PLASMA CYTOKINES IN HEMARTHROSIS: AN EXPERIMENTAL STUDY. ANNALS OF THE RHEUMATIC DISEASES, v. 75, p. 2-pg., 2016-06-01. (12/18588-1)