Acute effect of resistance training on inflammatory markers in individuals with rheumatoid arthritis

• Grant number: 12/20152-7
• Support Opportunities: Regular Research Grants
• Field of knowledge: Health Sciences - Physiotherapy and Occupational Therapy
• Principal Investigator: Império Lombardi Júnior
• Grantee: Império Lombardi Júnior
• Host Institution: Instituto de Saúde e Sociedade (ISS). Universidade Federal de São Paulo (UNIFESP). Campus Baixada Santista. Santos , SP, Brazil
• Associated researchers: Ana Carolina Pereira Nunes Pinto

Abstract

Rheumatoid arthritis (RA) is a systemic inflammatory disease, chronic, characterized by progressive polyarticular symmetrical which can lead to joint destruction and functional disability important. The biggest challenge in the management of the disease is severe and persistent inflammation of the synovium where there is an increase of 3 to 100 times of proinflammatory cytokines. Resistance training (RT) in patients with RA, improves functional capacity, providing gains in muscle mass and strength, without exacerbating disease activity or joint damage. Further, the TR has been recognized for positively modulate inflammation in healthy subjects. Objective: To evaluate the acute effect of a session of TR in serum tumor necrosis factor alpha, interleukin 1 receptor antagonist, C-reactive protein, interleukin 6, interleukin 10 and cartilage oligomeric matrix protein in patients with RA. Methodology: A prospective, controlled clinical trial. Respecting the criteria for inclusion and exclusion criteria will be recruited in the outpatient UNIFESP, 20 volunteers with RA (RA group) and 20 without the disease (the control group), which will be matched with individuals AR group with respect to age and gender . Participants will undergo a TR session, as specified in the study protocol. To evaluate the metabolic markers, blood samples will be obtained before and after the session TR. Dosages will be measured according to the ELISA method. This research will provide new information and to base future recommendations and collaborate so that treatment protocols are investigated by TR and aimed not only at improving the functional capacity of individuals with RA controlled, but also to combat inflammatory stages of disease. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

ANA CAROLINA PEREIRA NUNES PINTO; JAMIL NATOUR; IMPÉRIO LOMBARDI JUNIOR. Força muscular de membros inferiores em mulheres com artrite reumatoide e mulheres sem a doença: há diferença?. Fisioter. Pesqui., v. 25, n. 4, p. 364-368, 2018-12-00. (12/20152-7)

PEREIRA NUNES PINTO, ANA CAROLINA; NATOUR, JAMIL; DE MOURA CASTRO, CHARLLES HELDAN; ELOI, MARINA; LOMBARDI JUNIOR, IMPERIO. Acute effect of a resistance exercise session on markers of cartilage breakdown and inflammation in women with rheumatoid arthritis. INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES, v. 20, n. 11, p. 1704-1713, NOV 2017. (12/20152-7)