Bovine Herpesvirus 5: expression of apoptotic related genes in in vitro experiments

• Grant number: 12/16715-6
• Support Opportunities: Regular Research Grants
• Start date: June 01, 2013
• End date: May 31, 2015
• Field of knowledge: Agronomical Sciences - Veterinary Medicine - Preventive Veterinary Medicine
• Principal Investigator: Tereza Cristina Cardoso da Silva
• Grantee: Tereza Cristina Cardoso da Silva
• Host Institution: Faculdade de Medicina Veterinária (FMVA). Universidade Estadual Paulista (UNESP). Campus de Araçatuba. Araçatuba , SP, Brazil

Abstract

The Bovine Herpesvirus 5 type is closely related to meningoencephalitis nonsuppurative which is endemic in parts of Brazil, mainly in the South of the country. This fact, coupled with the in vitro production of embryos (PIV) and embryo transfer (et) cattle are considered reproductive biotechnologies, which are routinely applied in genetic improvement of the species. However, it remains to determine the extent to which its use implies the spread of pathogens in the herd. Recently, it has been shown clinical disease and infertility Board reproductive cows inseminated with semen good for BHV-5 (KIRKLAND et al., 2009). The neurological form of the disease are scarce in the States of São Paulo and Mato Grosso do Sul, and frequent in the South of the country. The present work aims to analyze the presence of expression of various genetic markers related to virus-cell interaction, once the BHV-5 has already been described in the nervous system, reproductive epithelium and bovine gametes. (AU)

Scientific publications

(6)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DA SILVA, SERGIO E. L.; FERREIRA, HELENA L.; GARCIA, ANDREA F.; SILVA, FELIPE E. S.; GAMEIRO, ROBERTO; FABRI, CAROLINA U. F.; VIEIRA, DIELSON S.; CARDOSO, TEREZA C.. Mitochondrial bioenergy alterations in avian HD11 macrophages infected with infectious bronchitis virus. ARCHIVES OF VIROLOGY, v. 163, n. 4, p. 1043-1049, APR 2018. (12/16715-6)

CARDOSO, T. C.; SAKAMOTO, S. S.; STOCKMANN, D.; SOUZA, T. F. B.; FERREIRA, H. L.; GAMEIRO, R.; VIEIRA, F. V.; LOUZADA, M. J. Q.; ANDRADE, A. L.; FLORES, E. F.. A three-dimensional cell culture system as an in vitro canine mammary carcinoma model for the expression of connective tissue modulators. VETERINARY AND COMPARATIVE ONCOLOGY, v. 15, n. 2, p. 582-593, JUN 2017. (12/16715-6)

CARDOSO, TEREZA C.; FERREIRA, HELENA. L.; OKAMURA, LUCAS H.; OLIVEIRA, BRUNA R. S. M.; ROSA, ANA CAROLINA G.; GAMEIRO, ROBERTO; FLORES, EDUARDO F.. Comparative analysis of the replication of bovine herpesvirus 1 (BHV1) and BHV5 in bovine-derived neuron-like cells. ARCHIVES OF VIROLOGY, v. 160, n. 11, p. 2683-2691, NOV 2015. (12/16715-6)

CARDOSO, T. C.; FERREIRA, H. L.; OKAMURA, L. H.; GIROTO, T. P.; OLIVEIRA, B. R. S. M.; FABRI, C. U. F.; GAMEIRO, R.; FLORES, E. F.. Cellular response markers and cytokine gene expression in the central nervous system of cattle naturally infected with bovine herpesvirus 5. VETERINARY JOURNAL, v. 218, p. 71-77, DEC 2016. (12/16715-6)

VIEIRA, FLAVIA V.; HOFFMANN, DANIEL J.; FABRI, CAROLINA U. F.; BRESCIANI, KATIA D. S.; GAMEIRO, ROBERTO; FLORES, EDUARDO F.; CARDOSO, TEREZA C.. Circulation of canine parvovirus among dogs living in human-wildlife interface in the Atlantic forest biome, Brazil. HELIYON, v. 3, n. 12, DEC 2017. (13/24951-4, 12/16715-6)

CARDOSO, TEREZA C.; OKAMURA, LUCAS H.; BAPTISTELLA, JAMILA C.; BORSANELLI, ANA CAROLINA; BAPTISTIOLLI, LILLIAN; FERREIRA, HELENA L.; GAMEIRO, ROBERTO; FLORES, EDUARDO F.. RETRACTED: Bovine Herpesvirus 5 promotes mitochondrial dysfunction in cultured bovine monocyte-derived macrophages and not affect virus replication (Retracted article. See vol. 235, pg. 327, 2019). Veterinary Microbiology, v. 229, p. 153-158, FEB 2019. (12/16715-6)