The interrelationship of birth weight, physical training and blood pressure levels: a clinical and experimental approach on the role of endothelial progenitor cells

• Grant number: 13/03139-0
• Support Opportunities: Regular Research Grants
• Start date: June 01, 2013
• End date: May 31, 2015
• Field of knowledge: Biological Sciences - Pharmacology - Cardiorenal Pharmacology
• Principal Investigator: Maria Do Carmo Pinho Franco
• Grantee: Maria Do Carmo Pinho Franco
• Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil
• Associated scholarship(s): 13/11714-4 - The interrelationship of birth weight, physical training and blood pressure levels: a clinical and experimental approach on the role of endothelial progenitor cells, BP.TT

Abstract

Several available evidence from clinical and experimental studies demonstrated that there is an excess risk of cardiovascular disease (CVD), type 2 diabetes, hypertension and metabolic syndrome among individuals with history of low birth weight (LBW). Recently, we demonstrated that LBW children had elevation of blood pressure levels associated with endothelial dysfunction. Moreover, we observed in these children increased circulating levels of uric acid and homocysteine, and these changes were accompanied by a decrease in the NO concentration. Experimental studies carried out by our group corroborate and extend these clinical findings. In these studies, we demonstrated that rats submitted to intrauterine undernutrition exhibited endothelial dysfunction characterized by decreased in NO synthesis and redox state unbalance via NADPH oxidase activation by angiotensin II. The aim of this study is to evaluate the clinical and experimental context in the involvement of the endothelial progenitor cells and its interaction with birth weight, blood pressure levels and physical training. Thus, contributing to better understanding of the role of low birth weight in the pathophysiology of cardiovascular diseases. (AU)

Scientific publications

(12)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

SOUZA, V, LIVIA; DE MENECK, FRANCIELE; FERNANDES, TIAGO; OLIVEIRA, EDILAMAR M.; FRANCO, MARIA DO C.. Physical activity intervention improved the number and functionality of endothelial progenitor cells in low birth weight children. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES, v. 30, n. 1, p. 60-70, JAN 3 2020. (13/03139-0)

OLIVEIRA, V.; SILVA JUNIOR, S. D.; DE CARVALHO, M. H. C.; AKAMINE, E. H.; MICHELINI, L. C.; FRANCO, M. C.. Intrauterine growth restriction increases circulating mitochondrial DNA and Toll-like receptor 9 expression in adult offspring: could aerobic training counteract these adaptations?. JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE, v. 8, n. 2, p. 236-243, APR 2017. (13/00311-6, 13/03139-0)

DE MENECK, F.; VICTORINO DE SOUZA, L.; OLIVEIRA, V; DO FRANCO, M. C.. High irisin levels in overweight/obese children and its positive correlation with metabolic profile, blood pressure, and endothelial progenitor cells. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES, v. 28, n. 7, p. 756-764, JUL 2018. (13/03139-0)

SOUZA, LIVIA VICTORINO; OLIVEIRA, VANESSA; DE MENECK, FRANCIELE; GROTTI CLEMENTE, ANA PAULA; LOUZADA STRUFALDI, MARIA WANY; FRANCO, MARIA DO CARMO. Birth Weight and Its Relationship with the Cardiac Autonomic Balance in Healthy Children. PLoS One, v. 12, n. 1, JAN 17 2017. (13/03139-0)

COSTA MACHADO, FERNANDA; SOUZA VITALLE, MARIA S.; FRANCO, MARIA. Predictors of depression and anxiety during adolescence: the impact of birth weight. MINERVA PEDIATRICA, v. 70, n. 5, p. 430-437, OCT 2018. (13/03139-0)

DE SOUZA, LIVIA VICTORINO; OLIVEIRA, VANESSA; LAURINDO, ALINE OLIVEIRA; HUARACHI, DELMAREGINA GOMES; KOCH NOGUEIRA, PAULO CESAR; FELTRAN, LUCIANA DE SANTIS; MEDINA-PESTANA, JOSE OSMAR; FRANCO, ANDMARIA DO CARMO. Serum Endocan Levels Associated with Hypertension and Loss of Renal Function in Pediatric Patients after Two Years from Renal Transplant. INTERNATIONAL JOURNAL OF NEPHROLOGY, v. 2016, p. 7-pg., 2016-01-01. (13/03139-0)

DE SOUZA, LIVIA VICTORINO; OLIVEIRA, VANESSA; LAURINDO, ALINE OLIVEIRA; HUARACHI, DELMAREGINA GOMES; KOCH NOGUEIRA, PAULO CESAR; FELTRAN, LUCIANA DE SANTIS; MEDINA-PESTANA, JOSE OSMAR; FRANCO, ANDMARIA DO CARMO. Serum Endocan Levels Associated with Hypertension and Loss of Renal Function in Pediatric Patients after Two Years from Renal Transplant. INTERNATIONAL JOURNAL OF NEPHROLOGY, 2016. (13/03139-0)

SOUZA, LIVIA VICTORINO; DE MENECK, FRANCIELE; OLIVEIRA, VANESSA; HIGA, ELISA MIEKO; AKAMINE, ELIANA HIROMI; FRANCO, MARIA DO CARMO. Beneficial Impact of Moderate to Vigorous Physical Activity Program on Circulating Number and Functional Capacity of Endothelial Progenitor Cells in Children: The Crucial Role of Nitric Oxide and VEGF-A. PEDIATRIC EXERCISE SCIENCE, v. 31, n. 3, p. 322-329, AUG 2019. (13/03139-0)

OLIVEIRA, V.; DE SOUZA, L. V.; FERNANDES, T.; JUNIOR, S. D. S.; DE CARVALHO, M. H. C.; AKAMINE, E. H.; MICHELINI, L. C.; DE OLIVEIRA, E. M.; FRANCO, M. D. C.. Intrauterine growth restriction-induced deleterious adaptations in endothelial progenitor cells: possible mechanism to impair endothelial function. JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE, v. 8, n. 6, p. 665-673, DEC 2017. (13/00311-6, 13/03139-0)

SANTOS, LARISSA BADIM; BORGES, LUANA MEIRELES; SOUZA, LIVIA VICTORINO; FELIPE, CLAUDIA ROSSO; MEDINA-PESTANA, JOSE OSMAR; FRANCO, MARIA DO CARMO. Is low birth weight an additional risk factor for hypertension in paediatric patients after kidney transplantation?. JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE, v. 11, n. 1, p. 3-6, FEB 2020. (13/03139-0)

SOUZA, LIVIA VICTORINO; DE MENECK, FRANCIELE; OLIVEIRA, VANESSA; HIGA, ELISA MIEKO; AKAMINE, ELIANA HIROMI; FRANCO, MARIA DO CARMO. Detrimental Impact of Low Birth Weight on Circulating Number and Functional Capacity of Endothelial Progenitor Cells in Healthy Children: Role of Angiogenic Factors. JOURNAL OF PEDIATRICS, v. 206, p. 72+, MAR 2019. (13/03139-0)

MACHADO, FERNANDA DA CONCEICAO; DE SOUZA, LIVIA VICTORINO; RANGEL, MARINA; JARA, ZAIRA PALOMINO; FRANCO, MARIA DO CARMO. Implication of galanin gene rs948854 polymorphism in depressive symptoms in adolescents. Hormones and Behavior, v. 97, p. 4-pg., 2018-01-01. (13/03139-0)