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Expression of genes involved in xenobiotic metabolism pathway in patients with head and neck cancer


Susceptibility to enviromental agents and its adverse effects health depends of the profile personal genetic. Estimate that great part of the neoplasias results of the interation between genetic and enviromental factors. Some individuals can present increased risk of develop the cacner due to defferences in biometabolism. This way, the individual differences can present as significant risk fator for neoplasias associated to smoking and drinking. Expression modification of the xenobiótic metabolizing genes, such as cytochrome P450 (CYP) family members, can be associated with head and neck carcinogenesis. However, studies are still necessary for a better understanding of this association. This study aims identify the pattern of the gene expression in patients with head and neck cancer, in order to identify susceptibility biomarkers of this cancer type, using eight patient tissue samples with pathological diagnosis of the head and neck squamous cell carcinoma and eight normal tissue samples adjacent. Evaluation of gene expression be performed by TaqMan® Array Human CYP450 and other Oxygenases, Fast 96-well Plate (Applied Biosystems) with triplicate reactions. Molecular findings and risk factors informations will be statistically evaluated. Results may contribute to the understanding the etiopathogenesis-related gene expression in the pathway of metabolism of xenobiotics in head and neck carcinogenesis. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
RUSSO, ANELISE; BISELLI-CHICOTE, PATRICIA M.; KAWASAKI-OYAMA, ROSA S.; CASTANHOLE-NUNES, MARCIA M. U.; MANIGLIA, JOSE V.; NETO, DALISIO DE SANTI; PAVARINO, ERIKA C.; GOLONI-BERTOLLO, ENY M. Differential Expression of Prostaglandin I2 Synthase Associated with Arachidonic Acid Pathway in the Oral Squamous Cell Carcinoma. JOURNAL OF ONCOLOGY, 2018. Web of Science Citations: 0.

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