Experimental study in minipigs of the efficacy and viability of the lateral laryngotomy for access to the laryngeal vestibule

• Grant number: 05/03205-6
• Support Opportunities: Regular Research Grants
• Start date: January 01, 2006
• End date: December 31, 2006
• Field of knowledge: Health Sciences - Medicine
• Principal Investigator: Paulo Augusto de Lima Pontes
• Grantee: Paulo Augusto de Lima Pontes
• Host Institution: Departamento de Otorrinolaringologia. Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil

Abstract

The surgical illnesses of the larynx can be approached by transoral (microlaryngoscopic) and transcervical (thyrotomies and laryngectomies) techniques. The transoral access is the one favoured by every surgeon when there is good surgical conditions, since it is less invasive e aggressive. However, there are patients that present access impossibility, be for they present tumors of great extension or for they are bearers of deformities avoiding laryngeal intubation. One of the possibilities to outline these situations is the opening of the larynx through its thyroid cartilage. However it is necessary to collect more information as the viability of this technique be in the postop maintenance of the laryngeal anatomy after the procedure and the capacity of this access in offering appropriate surgical conditions. Objective: To develop a new technique of surgical access to the larynx, testing its application through experimental surgery in animals (minipigs), aiming to determine the visual and surgical instrumental accessibility to the operative field, besides determining the possible complications and the anatomical repercussions in its execution. Study Design: Experimental, surgical in minipigs. Material and Method: 10 minipigs of 6 months of age and about 30-35kgs will be used. The procedures will be accomplished under general anesthesia. There will be two control animals for each phase of the procedure and 6 for the complete procedure. The animals will be followed in biotery for 21 days and, soon afterwards, submitted to euthanasia under general anesthesia. The larynxes will be excized and submitted to pathological exam for evaluation of inflammatory and cicatrizational conditions. The technique of lateral laringotomy will be defined by a previous cervical access, subcutaneous debridment, thyroid cartilage exposition, superioly pedicled trap door windowconfection and opening of laryngeal mucous membrane in the ventricle... (AU)