Use of palladium (II) pyrazolyl complexes in host-guest, biological and catalytic systems

• Grant number: 05/04285-3
• Support Opportunities: Regular Research Grants
• Start date: April 01, 2006
• End date: March 31, 2008
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Inorganic Chemistry
• Principal Investigator: Antonio Eduardo Mauro
• Grantee: Antonio Eduardo Mauro
• Host Institution: Instituto de Química (IQ). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil

Abstract

The coordination chemistry of pyrazoles has become an interesting research area not only due to the great structural variety of its derivatives but also by its highly multidisciplinary character. In particular, palladium(II) pyrazolyl complexes have attracted considerable attention because of their supramolecular chemistry as well their biological and catalytic properties. Supramolecular species with large cavities able to accommodate small molecules are of interest in the manufacturing of new molecular sensors. In this context, the synthesis, characterization and investigation of host-guest properties of the species of general formulae [Pd(u-Pz*)2(L)]3 and [Pd3(u-N3)(u-Pz*)5]n (L = bis-2,2-imydazole, bis-2,2-pyrimidine; Pz* = pyrazolates) are proposed in this work. The determination of the cell viability of murine peritoneal macrophages by the IC50 of the complexes of general formulae cis-[PdX2(tdmPz)] (tdmPz = 3,5-dimethyl-1-thiocarbamoylpyrazole) and [PdX(HPz*)L]X (HPz* = pyrazoles; L = bidentate phosphines; X = halides and pseudohalides) as well their influence on releasing of H2O2, NO and TNF-alpha are also objectives of the proposed research. The cytotoxicity of these complexes towards LMM3 tumoral cells will be investigated and compared to cisplatin as reference. This study will be carried out at the Departamento de Análises Clínicas of Faculdade de Ciências Farmacêuticas (UNESP), under supervision of Profa. Dra. Iracilda Zeppone Carlos... (AU)