There is no relationship between paraoxonase serum level activity in women with endometriosis and the stage of the disease: an observational study

• Grant number: 13/12427-9
• Support Opportunities: Regular Research Grants - Publications - Scientific article
• Start date: August 01, 2013
• End date: January 31, 2014
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Bianca Alves Vieira Bianco
• Grantee: Bianca Alves Vieira Bianco
• Host Institution: Faculdade de Medicina do ABC (FMABC). Organização Social de Saúde. Fundação do ABC. Santo André , SP, Brazil

Abstract

Background: evidence suggesting a link with oxidative stress. Paraoxonase is a serum enzyme which circulates associated with high-density lipoprotein (HDL). It acts protecting HDL and LDL of lipid peroxidation. We aimed to compare the serum levels of PON-1 activity in women with endometriosis in different stages of the disease (minimal/mild and moderate/severe). 80 infertile women with endometriosis diagnosed by laparoscopy/laparotomy with histologic confirmation of the disease were divided according to the American Society for Reproductive Medicine classification in minimal/mild (n=33) and moderate/severe (n=47) cases. Paraoxonase activity and arilesterase activity were measured by spectrophotometry. Body mass index and fasting glucose levels were also determined. The paraoxonase activity were 191.29 ± 22.41 U/l in women with minimal/mild endometriosis and 224.85 ± 21.50 U/l in women with moderate/severe disease (P=0.274). Considering arilesterase level, the results showed 89.82 ± 4.61 U/l in women with minimal/mild endometriosis and 90.78 ± 3.43 U/l in moderate/severe disease (P=0.888). Evidence of lower paraoxonase activity in women with endometriosis was not found in this study. Besides, no difference was found considering minimal/mild or moderate/severe endometriosis. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

BRAGATTO, FELIPE BARCA; BARBOSA, CAIO PARENTE; CHRISTOFOLINI, DENISE MARIA; PELUSO, CARLA; DOS SANTOS, ALINE AMARO; MAFRA, FERNANDA ABANI; CAVALCANTI, VIVIANE; HIX, SONIA; BIANCO, BIANCA. There is no relationship between Paraoxonase serum level activity in women with endometriosis and the stage of the disease: an observational study. Reproductive Health, v. 10, JUN 22 2013. (13/12427-9)