Investigation of the role of non carboxilated osteocalcin in pancreatic beta cells function in healthy, type 1 Diabetes mellitus and obese adolescents

• Grant number: 13/04454-6
• Support Opportunities: Regular Research Grants
• Start date: December 01, 2013
• End date: November 30, 2015
• Field of knowledge: Health Sciences - Medicine
• Principal Investigator: Bruno Geloneze Neto
• Grantee: Bruno Geloneze Neto
• Host Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated researchers: Bruno Geloneze Neto

Abstract

Osteocalcin is a protein with a well defined function in bone tissue. Recently it was demonstrated that the circulated non carboxilated form may function as a hormone, having a positive influence in insulin production from the pancreatic beta cells and its sensitivity in peripheral tissues, and also an increase in adiponectin secretion. Thus, we hypothesized that by its association with energetic metabolism, osteocalcin is associated with insulin sensitivity acting in Metabolic Syndrome and it is altered in type 1 diabetes mellitus (DM1) and obese patients. The objective of this project is to evaluate the role of non carboxilated osteocalcin in healthy, DM1 and obese patients. Three groups of post-pubertal adolescents will be enrolled: a group of 20 individuals with DM1, 40 individuals with obesity and 40 healthy individuals. Physical, anthropometric, body composition and biochemical evaluations will be performed in all individuals and hyperglycemic clamp will be performed in a sample from the healthy control and obese group. Association and correlation among non carboxilated osteocalcin measurements, serum adiponectin and degree of beta cell function in different groups with anthropometric and body composition evaluation will be investigated. This work will contribute to the understanding of osteocalcin secretion pattern in normal and pathologic estates and its relation with the energetic metabolism. (AU)