Relevance of arginase genetic polymorphisms to erectile dysfunction

• Grant number: 13/13346-2
• Support Opportunities: Regular Research Grants
• Start date: February 01, 2014
• End date: January 31, 2016
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Jose Eduardo Tanus dos Santos
• Grantee: Jose Eduardo Tanus dos Santos
• Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Abstract

The advancement of knowledge of genetic variations in the human genome has allowed improved understanding of their effects on human diseases. It is well known that genetic variations may affect disease susceptibility. Genetic variations named single nucleotide polymorphisms (SNPs) are very common and are markers of important diseases. This study aims at examining the association between erectile dysfunction and genetic polymorphisms in arginase I and II, and their association with enzyme activity and nitrite levels (which is a metabolite of endógenous nitric oxide - NO - that may be converted back to NO). This is relevant because those enzymes compete with NO synthases for L-arginine and therefore reduce endogenous NO formation. This may contribute to impaiment of erectile function and cause erectile dysfunction. In this Project, we also aim at using genotype information to obtain haplotype (combinations of genetic markers) using the Phase software, which may lead to more relevant clinical information than the analysis of single genotypes. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

LACCHINI, RICCARDO; MUNIZ, JAQUELINE J.; NOBRE, YURI T. D. A.; COLOGNA, ADAUTO J.; MARTINS, ANTONIO C. P.; TANUS-SANTOS, JOSE E.. nNOS polymorphisms are associated with responsiveness to sildenafil in clinical and postoperative erectile dysfunction. PHARMACOGENOMICS, v. 15, n. 6, p. 775-784, APR 2014. (13/13346-2)

LACCHINI, RICCARDO; MUNIZ, JAQUELINE J.; NOBRE, YURI T. D. A.; COLOGNA, ADAUTO J.; MARTINS, ANTONIO C. P.; TANUS-SANTOS, JOSE E.. Relationship between Arginase 1 and Arginase 2 levels and genetic polymorphisms with erectile dysfunction. NITRIC OXIDE-BIOLOGY AND CHEMISTRY, v. 51, p. 36-42, DEC 1 2015. (13/13346-2)