Analysis of the expression of miRNAs in acute atrial fibrillation patients the post operative myocardial revascularization

• Grant number: 13/18484-4
• Support Opportunities: Regular Research Grants
• Start date: February 01, 2014
• End date: January 31, 2016
• Field of knowledge: Health Sciences - Medicine - Surgery
• Principal Investigator: Pedro Silvio Farsky
• Grantee: Pedro Silvio Farsky
• Host Institution: Instituto Dante Pazzanese de Cardiologia (IDPC). Fundação Adib Jatene (FAJ). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
• Associated researchers: Andre Feldman ; Carlos Gun ; Dalmo Antonio Ribeiro Moreira ; Mario Hiroyuki Hirata ; Paula Helena Ortiz Lima

Abstract

Patients with atrial fibrillation in the post-operative period (FAPO) present higher mortality and higher in-hospital stay than those who does not. The possibility to identify patients in risk of developing FAPO generates the potential benefit in its prevention through the use of anti-arrhythmic agents. Micro RNAs are small fragments of RNA recently associated to the development of some diseases including those related to the circulatory system. Thus, the authors propose this study in order to identify the micro RNAs associated to the development of FAPO. In the first phase (screening), two groups with five patients with and without FAPO will be compared regarding to the presence or ausence of micro RNAs existence by mapping all the possible micro RNAs. In the second phase, two groups with fifty patients each will be submitted to the comparison of the micro RNAs found in the first phase. To identify the micro RNAs will be used peripheral venous blood samples and atrial tissue obtained in the intra operative period. Data will be submitted to statistical analysis. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

FELDMAN, ANDRE; RIBEIRO MOREIRA, DALMO ANTONIO; GUN, CARLOS; WANG, HUI-TZU LIN; HIRATA, MARIO HIROYUKI; GERMANO, JULIANA DE FREITAS; SOUSA LEITE, GABRIELA GUIMARAES; FARSKY, PEDRO. Analysis of Circulating miR-1, miR-23a, and miR-26a in Atrial Fibrillation Patients Undergoing Coronary Bypass Artery Grafting Surgery. ANNALS OF HUMAN GENETICS, v. 81, n. 3, p. 99-105, MAY 2017. (13/18484-4)