Use of branched 1,3/1,6 b-glucan, macrogard R, waste production of sugar and ethanol from baker's yeast, to stimulate the innate immune system of farmed fish

• Grant number: 13/50418-1
• Support Opportunities: Regular Research Grants
• Start date: February 01, 2014
• End date: December 31, 2018
• Field of knowledge: Agronomical Sciences - Fishery Resources and Fishery Engineering - Aquaculture
• Agreement: Netherlands Organisation for Scientific Research (NWO)
• Principal Investigator: Fabiana Pilarski
• Grantee: Fabiana Pilarski
• Principal researcher abroad: Geert Wiegertjes
• Institution abroad: Wageningen University, Netherlands
• Host Institution: Centro de Aquicultura (CAUNESP). Universidade Estadual Paulista (UNESP). Campus de Jaboticabal. Jaboticabal , SP, Brazil

Abstract

Glucan as waste materiais from bioethanol production, can have potent immunomodulatory effects that are thought to be medíated via the innate immune system and involve leucocytes with their associated glucan receptors. A thorough analysis of the enhanced immunocompetence by -glucans, especially in warm-water fish such as pacu, is missing. Details of how immunostimulants (-glucans) could activate receptors on fish macrophages are lacking because of límited knowledge on the ligand-receptor interactions. We propose an integrated approach to the study of -glucan-cell interactions in common carp and pacu, fish species important for aquaculture. This knowledge will substantiate the use of -glucans for immunostimulation of fish. The valorisation of glucan 'waste' from bioethanol as immunostimulant for aquaculture fit well the biorefinerv research theme aiming at optimized utilization of raw materiais. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DE JESUS, RAPHAEL B.; PETIT, JULES; PILARSKI, FABIANA; WIEGERTJES, GEERT F.; KOCH, JOAO FERNANDO A.; DE OLIVEIRA, CARLOS A. F.; ZANUZZO, FABIO S.. An early beta-glucan bath during embryo development increases larval size of Nile tilapia. AQUACULTURE RESEARCH, v. 50, n. 7, p. 2012-2014, JUL 2019. (13/50418-1)