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Evaluation of genotoxic and antioxidant activities of Styrax camporum hydroalcoholic extract and their chemical markers, egonol and homoegonol, and their influence on genomic and pre-neoplasic lesions

Abstract

The Styracaceae family is popularly known due to the production of balsamic resins with bacteriostatic and fungicidal properties called for "benjoin," in which the benzoic acid is the main constituent. This resin is widely used in traditional medicine for the treatment of respiratory disorders. The genus Styrax is the most important representative of Styracaceae family because it has about 130 species and a wealth of information. This genus differs from other genera of the family by producing a resinous material secreted from injuries caused by the stem. Different classes of special metabolites as lignans, neolignans, benzofuran norlignans and triterpenes constituents were found as prevalent in the genus. The Styrax camporum Poh is popularly known as "benjoeiro", "estoraque-do-campo" and "cuia-do-brejo". An adult plant can reach a height from 60 to 10 meters and trunk diameter from 30 to 40 inches. In Brazil, it occurs in the Cerrado of Minas Gerais, São Paulo, Mato Grosso do Sul and in semi-deciduous forest of the Paraná Basin. The ethnopharmacology reports the use of S. camporum to treat stomach problems. Phytochemical studies have shown egonol and homoegonol benzofurans lignans as chemical markers of the genus Styrax. Some important biological activities have been described in the literature for these compounds, such as antiproliferative, antibacterial, antifungal and immunomodulatory activities. Since the biological activities displayed by the extract and the egonol and homoegonol compounds its may have important clinical applications, it is important to evaluate its effect on genetic material, as well as its influence on genomic lesions induced by different mutagens. In this sense, the aim of the study will be evaluate the possible genotoxicity and carcinogenicity activities of the S. camporum hydroalcoholic stems extract and its chemical markers, egonol and homoegonol, as well to evaluate its modulating effect of DNA damage induced by mutagens with different mechanisms of action. Additionally, this study aims to carry out a series of measurements of products of oxidative stress in order to better understand the effect of the extract and its chemical markers in the body. For these evaluations, systems-test in vivo and in vitro will be used. (AU)

Scientific publications (8)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CARNIZELLO, ANDREA P.; ALVES, JACQUELINE M.; PEREIRA, DAIANE E.; CAMPOS, JACQUELINE C. L.; BARBOSA, MARILIA I. F.; BATISTA, ALZIR A.; TAVARES, DENISE C. Study of the cytotoxic and genotoxic potential of the carbonyl ruthenium(II) compound, ct-[RuCl(CO)(dppb)(bipy)]PF6 [dppb=1,4-bis(diphenylphosphino)butane and bipy=2,2 `-bipyridine], by in vitro and in vivo assays. JOURNAL OF APPLIED TOXICOLOGY, v. 39, n. 4, p. 630-638, APR 2019. Web of Science Citations: 1.
FERREIRA, NATALIA HELEN; FURTADO, RICARDO ANDRADE; RIBEIRO, ARTHUR BARCELOS; DE OLIVEIRA, POLLYANNA FRANCIELLI; OZELIN, SAULO DUARTE; RIBEIRO DE SOUZA, LARISSA DANIELA; NETO, FRANCISCO RINALDI; MIURA, BARBARA AYUMI; MAGALHAES, GEORGIA MODE; NASSAR, EDUARDO JOSE; TAVARES, DENISE CRISPIM. Europium(III)-doped yttrium vanadate nanoparticles reduce the toxicity of cisplatin. Journal of Inorganic Biochemistry, v. 182, p. 9-17, MAY 2018. Web of Science Citations: 2.
NICOLELLA, HELOIZA DINIZ; NETO, FRANCISCO RINALDI; CORREA, MARIANA BELTRAME; LOPES, DANILLO HENRIQUE; RONDON, EDILAURA NUNES; RIBEIRO DOS SANTOS, LUIZ FELIPE; DE OLIVEIRA, POLLYANNA FRANCIELLI; DAMASCENO, JAQUELINE LOPES; ACESIO, NATHALIA OLIVEIRA; CASANOVA TURATTI, IZABEL CRISTINA; TOZATTI, MARCOS GOMIDE; CUNHA, WILSON ROBERTO; FURTADO, RICARDO ANDRADE; TAVARES, DENISE CRISPIM. Toxicogenetic study of Persea americana fruit pulp oil and its effect on genomic instability. Food and Chemical Toxicology, v. 101, p. 114-120, MAR 2017. Web of Science Citations: 3.
ACESIO, NATHALIA OLIVEIRA; CARRIJO, GUILHERME SCARANO; BATISTA, THALES HENRIQUE; DAMASCENO, JAQUELINE LOPES; CORREA, MARIANA BELTRAME; TOZATTI, MARCOS GOMIDE; CUNHA, WILSON ROBERTO; TAVARES, DENISE CRISPIM. Assessment of the antioxidant, cytotoxic, and genotoxic potential of the Annona muricata leaves and their influence on genomic stability. JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES, v. 80, n. 23-24, p. 1290-1300, 2017. Web of Science Citations: 8.
CARNIZELLO, ANDREA P.; BARBOSA, MARILIA I. F.; MARTINS, MONIZE; FERREIRA, NATALIA H.; OLIVEIRA, POLLYANNA F.; MAGALHAES, GEORGIA M.; BATISTA, ALZIR A.; TAVARES, DENISE C. In vitro and in vivo antitumor activity of a novel carbonyl ruthenium compound, the ct-[RuCl(CO)(dppb)(bipy)]PF-6[dppb=1,4-bis(diphenylphosphine)butane and bipy=2,2 `-bipyridine]. Journal of Inorganic Biochemistry, v. 164, p. 42-48, NOV 2016. Web of Science Citations: 10.
DE OLIVEIRA, POLLYANNA FRANCIELLI; DAMASCENO, JAQUELINE LOPES; NICOLELLA, HELOIZA DINIZ; BERTANHA, CAMILA SPERETA; PAULETTI, PATRICIA MENDONCA; TAVARES, DENISE CRISPIM. Influence of Styrax camporum and of Chemical Markers (Egonol and Homoegonol) on DNA Damage Induced by Mutagens with Different Mechanisms of Action. BIOLOGICAL & PHARMACEUTICAL BULLETIN, v. 39, n. 11, p. 1839-1845, NOV 2016. Web of Science Citations: 1.
DE OLIVEIRA, POLLYANNA FRANCIELLI; DAMASCENO, JAQUELINE LOPES; BERTANHA, CAMILA SPERETA; BARBOSA ARAUJO, ALBA REGINA; PAULETTI, PATRICIA MENDONCA; TAVARES, DENISE CRISPIM. Study of the cytotoxic activity of Styrax camporum extract and its chemical markers, egonol and homoegonol. Cytotechnology, v. 68, n. 4, p. 1597-1602, AUG 2016. Web of Science Citations: 5.
FERREIRA, NATALIA HELEN; BARBOSA DE ANDRADE, KELLY JACQUELINE; LEANDRO, LUIS FERNANDO; ACESIO, NATHALIA OLIVEIRA; MENDES, SUZANA AMORIM; CINTRA, LUCAS SILVA; JANUARIO, ANA HELENA; TAVARES, DENISE CRISPIM. Testing of Schefflera vinosa extract in mammalian cells in vitro and in vivo for potential toxicity, genetic damage, and role of oxidation. JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES, v. 79, n. 24, p. 1201-1210, 2016. Web of Science Citations: 6.

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