Prevention of transfusional transmitted malaria in São Paulo State

• Grant number: 14/50093-8
• Support Opportunities: Research Grants - Research in Public Policies for the National Health Care System (PP-SUS)
• Start date: July 01, 2014
• End date: March 31, 2016
• Field of knowledge: Health Sciences - Medicine
• Agreement: CNPq - PPSUS
• Principal Investigator: José Eduardo Levi
• Grantee: José Eduardo Levi
• Host Institution: Hemocentro de São Paulo. Fundação Pró-Sangue. Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil

Abstract

Although in small numbers, the state of São Paulo presents autochthonous malaria cases. Wherever malaria cases occur, for every symptomatic patient there is a larger number of individuals who are asymptomatic carriers of Plasmodium, in general harboring low parasitemia. In Brazil, blood donors are submitted to some kind of malaria test only when they inhabit or come from the Amazon, so the applied measure does not foresee the existence of individual who are infected in the state of São Paulo itself (or outside the Amazon region ). Transfusional malaria cases continue to occur in São Paulo, being particularly severe in splenectomized individuals, either surgically or functionally as chronically transfused sickle cell disease patients. Donors involved in these episodes of transfusion transmission are always individuals who visited the Atlantic Forest in different regions of the state and are unaware of their Plasmodium carrier status. The aim of this project is to elaborate some questions about the connection between blood donor candidates and the Atlantic Forest, and evaluate the effectiveness of these questions to identify those with positive laboratory tests for Plasmodium. Hopefully, these data will allow us to propose an algorithm for screening of blood donors and increasing transfusion safety in our state. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

LIMA, GISELLE F. M. C.; ARROYO SANCHEZ, MARIA C.; LEVI, JOSE E.; FUJIMORI, MAHYUMI; CARAMELO, LUIZA DA CRUZ; SANCHEZ, ARIANNI RONDELLI; RAMOS-SANCHEZ, EDUARDO M.; INOUE, JULIANA; COSTA-NASCIMENTO, MARIA DE JESUS; MENDRONE JUNIOR, ALFREDO; et al. Asymptomatic infections in blood donors harbouring Plasmodium: an invisible risk detected by molecular and serological tools. BLOOD TRANSFUSION, v. 16, n. 1, p. 17-25, 2018. (12/18014-5, 14/50093-8)

MARIANA ASCHAR; JOSÉ EDUARDO LEVI; MARIA L. R. N. FARINAS; SANDRA C. MONTEBELLO; ALFREDO MENDRONE-JUNIOR; SILVIA MARIA DI SANTI. The hidden Plasmodium malariae in blood donors: a risk coming from areas of low transmission of malaria. Revista do Instituto de Medicina Tropical de São Paulo, v. 62, 2020-12-18. (14/50093-8)

LEVI, JOSE EDUARDO. Emerging Infectious Agents and Blood Safety in Latin America. FRONTIERS IN MEDICINE, v. 5, MAR 14 2018. (14/50093-8)