Study of the association between HLA antigens - Dr and DQ - and pemphigus vulgaris in Brazilian patients

• Grant number: 13/23678-2
• Support Opportunities: Regular Research Grants
• Start date: August 01, 2014
• End date: July 31, 2015
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Ivan Dieb Miziara
• Grantee: Ivan Dieb Miziara
• Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated researchers: Jorge Elias Kalil Filho ; Julio Miranda Gil

Abstract

Pemphigus Vulgaris has been associated to HLA alleles in different populations, mainly HLA-DRB1*04:02 and HLA-DQB1*05:03. However, these alleles are not always present in PV patients. Preliminary study of this institution has investigated the possible correlation between HLA-DR alleles and Pemphigus Vulgaris by typing a cohort of 36 patients and 162 healthy controls from a Brazilian highly admixed population. Significantly higher frequencies of HLA DRB1*04:02, DRB1*08:04, and DRB1*14 alleles were observed in the patients than in the control individuals (47.2% vs. 1.2%; 36.1% vs. 4.3%; 27.8% vs. 7.4%, respectively). This work describes for the first time a strong association between the DRB1*08:04 allele and pemphigus vulgaris in the Brazilian population. The results raise a suspicion of the DRB1*08:04 allele being involved with the disease. The present study has the purpose of doing a High-resolution typing of nearby loci DQA1 and DQB1 on the previously extracted DNA to differentiate if the association is inherent to the HLA-DRB1*08:04 allele or to a specific haplotype and also will amplify the number of patients into fifty six, by typing HLA-DR and DQ in all of them. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

GIL, JULIO M.; WEBER, RAIMAR; ROSALES, CLAUDIA B.; RODRIGUES, HELCIO; SENNES, LUIZ U.; KALIL, JORGE; CHAGURY, AZIS; MIZIARA, IVAN D.. Study of the association between human leukocyte antigens (HLA) and pemphigus vulgaris in Brazilian patients. INTERNATIONAL JOURNAL OF DERMATOLOGY, v. 56, n. 5, p. 557-562, MAY 2017. (13/23678-2)