Identification of molecular markers for cancer diagnosis and prognosis using DNA microarrays

• Grant number: 02/13283-6
• Support Opportunities: Research Projects - Thematic Grants
• Start date: July 01, 2004
• End date: August 31, 2008
• Field of knowledge: Biological Sciences - Biochemistry - Molecular Biology
• Principal Investigator: Sergio Verjovski Almeida
• Grantee: Sergio Verjovski Almeida
• Host Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Pesquisadores principais: Aline Maria da Silva ; Eduardo Moraes Rego Reis
• Associated scholarship(s): 07/56390-0 - Functional characterization of totally intronic long noncoding RNAs (TiN RNAs) in cell processes related to tumorigenesis, BP.DD; 06/57605-8 - Biogenesis of intronic RNAs and their involvement in splicing of exons regulation of protein coding genes, BP.PD; 02/02689-1 - Identification and characterization of prostate tumor marker candidates, BP.DD

Abstract

The present project is an extension of the CAGE project - Cooperation for Analysis of Gene Expression - and it proposes to advance in the characterization of prognostic markers in cancer through the association with clinical groups which have access to a large number of well-supervised patients, for whom the clinical evolution is known. An important advance is related to the fact that the clinical groups currently involved, from the Sírio Libanês Hospital in São Paulo, and from the Unicamp Hemocenter in Campinas, have proven experience in the study of different sub-types of prostate and kidney cancers, leukemias and lymphomas. These groups now have a tumor bank with hundreds of samples of fresh tissue preserved by freezing, a much higher number of patients than that found up to the present time in the literature that used DNA microarray technology in the study of cancer. In addition to this, these groups hold the clinical and pathological information from supervised patients which goes back as far as 5 years ago, and which is of recognized prognostic value. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

BRITO, GLAUBER COSTA; FACHEL, ANGELA A.; VETTORE, ANDRE LUIZ; VIGNAL, GISELLE M.; GIMBA, ETEL R. P.; CAMPOS, FRANZ S.; BARCINSKI, MARCELLO A.; VERJOVSKI-ALMEIDA, SERGIO; REIS, EDUARDO M.. Identification of protein-coding and intronic noncoding RNAs down-regulated in clear cell renal carcinoma. Molecular Carcinogenesis, v. 47, n. 10, p. 757-767, Oct. 2008. (02/13283-6)

LOURO‚ R.; NAKAYA‚ H.; AMARAL‚ P.; FESTA‚ F.; SOGAYAR‚ M.; DA SILVA‚ A.; VERJOVSKI-ALMEIDA‚ S.; REIS‚ E.. Androgen responsive intronic non-coding RNAs. BMC Biology, v. 5, n. 1, p. 4, 2007. (01/10707-7, 02/13283-6)

Filed patent(s) as a result of this research project