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Phenotypic and genotypic profiles of Aggregatibacter actinomycetemcomitans e Fusobacterium nucleatum from patients with different clinical status: qualitative and quantitative determinations

Grant number: 13/13652-6
Support type:Regular Research Grants
Duration: October 01, 2014 - September 30, 2016
Field of knowledge:Health Sciences - Dentistry
Principal Investigator:Mario Júlio Ávila-Campos
Grantee:Mario Júlio Ávila-Campos
Home Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Aggregatibacter actinomycetemcomitans and Fusobacterium nucleatum belong to the oral resident microbiota. These gram-negative oral bacteria are implicated in the development and progression of the periodontal disease. In this study, 1) the occurrence of A. actinomycetemcomitans and F. nucleatum in healthy subjects and patients with gingivitis and chronic periodontitis; 2) the occurrence of biotypes and serotypes of A. actinomycetemcomitans; 3) the quantitative determination both microorganisms from the three patient's groups; and 4) the determination of the genetic diversity profile of both A. actinomycetemcomitans and F. nucleatum will be determined. This study is important because the results will take a better knowledge about ecological aspects and the role of these periodontopathogens in the development and progression of the periodontal disease. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ARENAS RODRIGUES, VIVIANE APARECIDA; DE AVILA, ERICA DORIGATTI; NAKANO, VIVIANE; AVILA-CAMPOS, MARIO JULIO. Qualitative, quantitative and genotypic evaluation of Aggregatibacter actinomycetemcomitans and Fusobacterium nucleatum isolated from individuals with different periodontal clinical conditions. Anaerobe, v. 52, p. 50-58, AUG 2018. Web of Science Citations: 7.
PEREIRA, R. S.; RODRIGUES, V. A. A.; FURTADO, W. T.; GUEIROS, S.; PEREIRA, G. S.; AVILA-CAMPOS, M. J. Microbial analysis of root canal and periradicular lesion associated to teeth with endodontic failure. Anaerobe, v. 48, p. 12-18, DEC 2017. Web of Science Citations: 5.
SILVA, AMANDA DO NASCIMENTO; DE AVILA, ERICA DORIGATTI; NAKANO, VIVIANE; AVILA-CAMPOS, MARIO J. Pathogenicity and genetic profile of oral Porphyromonas species from canine periodontitis. ARCHIVES OF ORAL BIOLOGY, v. 83, p. 20-24, NOV 2017. Web of Science Citations: 2.

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