Understanding the catabolic and anabolic effect of inflammation on bone tissue.

• Grant number: 14/05283-3
• Support Opportunities: Research Grants - Young Investigators Grants
• Start date: November 01, 2014
• End date: January 31, 2018
• Field of knowledge: Health Sciences - Dentistry - Periodontology
• Principal Investigator: Pedro Paulo Chaves de Souza
• Grantee: Pedro Paulo Chaves de Souza
• Host Institution: Faculdade de Odontologia (FOAr). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil
• City of the host institution: Araraquara
• Associated researchers: Carlos Alberto de Souza Costa ; João Antonio Chaves de Souza ; Petra Henning ; Ulf Holger Lerner
• Associated research grant(s): 16/50019-8 - Molecular mechanisms involved in osteoimmunomodulatory properties of biomaterials. (sprint 4/2015), AP.R SPRINT
• Associated scholarship(s): 15/00410-0 - OSM-SHC1 axis - a new pathway for osteoblast differentiation., BP.IC

Abstract

Inflammation close to bone causes its destruction. The common sense is that cytokines and inflammatory mediators are released from inflammatory cells and stimulate osteoclasts to resorb bone and inhibit osteoblasts to synthesize new bone. However, recent data from our group demonstrate that inflammation also leads to bone formation. Thus, bone formation and resorption happen at the same time during inflammation, but the processes are uncoupled. In this project, we aim to study the role of inflammatory mediators and substances that may interfere on bone modeling. In the first subproject, the role of kinin receptors on osteoclastogenesis will be studied. In the second project, the anabolic effect of oncostatin M will be dissected, aiming to discover a new signaling pathway. In the third subproject, the first two projects will be used in a translational study, which will aim to investigate the effect of biomaterials on bone tissue. (AU)

Scientific publications

(12)

(The scientific publications listed on this page originate from the Web of Science or SciELO databases. Their authors have cited FAPESP grant or fellowship project numbers awarded to Principal Investigators or Fellowship Recipients, whether or not they are among the authors. This information is collected automatically and retrieved directly from those bibliometric databases.)

JOÃO ANTONIO CHAVES DE SOUZA; FERNANDO AUGUSTO CINTRA MAGALHÃES; GUILHERME JOSE PIMENTEL LOPES DE OLIVEIRA; RAFAEL SCAF DE MOLON; JOSÉ ANTONIO ZUANON; PEDRO PAULO CHAVES DE SOUZA. Pam2CSK4 (TLR2 agonist) induces periodontal destruction in mice. Brazilian Oral Research, v. 34, 2020-02-10. (15/21697-5, 14/05283-3)

DE SOUZA, PEDRO P. C.; HENNING, PETRA; LERNER, ULF H.. Stimulation of Osteoclast Formation by Oncostatin M and the Role of WNT16 as a Negative Feedback Regulator. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 23, n. 6, p. 22-pg., 2022-03-01. (14/05283-3, 15/00410-0)

SOUZA, PEDRO P. C.; LERNER, ULF H.. Finding a Toll on the Route: The Fate of Osteoclast Progenitors After Toll-Like Receptor Activation. FRONTIERS IN IMMUNOLOGY, v. 10, JUL 17 2019. (14/05283-3)

PERSSON, EMMA; SOUZA, PEDRO P. C.; FLORIANO-MARCELINO, THAIS; CONAWAY, HOWARD HERSCHEL; HENNING, PETRA; LERNER, ULF H.. Activation of Shc1 Allows Oncostatin M to Induce RANKL and Osteoclast Formation More Effectively Than Leukemia Inhibitory Factor. FRONTIERS IN IMMUNOLOGY, v. 10, MAY 28 2019. (14/05283-3, 15/00410-0)

MOVERARE-SKRTIC, SOFIA; NILSSON, KARIN H.; HENNING, PETRA; FUNCK-BRENTANO, THOMAS; NETHANDER, MARIA; RIVADENEIRA, FERNANDO; NUNES, GLAUCIA COLETTO; KOSKELA, ANTTI; TUUKKANEN, JUHA; TUCKERMANN, JAN; et al. Osteoblast-derived NOTUM reduces cortical bone mass in mice and the NOTUM locus is associated with bone mineral density in humans. FASEB JOURNAL, v. 33, n. 10, p. 11163-11179, OCT 2019. (14/05283-3)

CHAVES DE SOUZA, JOAO ANTONIO; CINTRA MAGALHAES, FERNANDO AUGUSTO; PIMENTEL LOPES DE OLIVEIRA, GUILHERME JOSE; DE MOLON, RAFAEL SCAF; ZUANON, JOSE ANTONIO; CHAVES DE SOUZA, PEDRO PAULO. Pam2CSK4 (TLR2 agonist) induces periodontal destruction in mice. BRAZILIAN ORAL RESEARCH, v. 34, p. 10-pg., 2020-01-01. (15/21697-5, 14/05283-3)

TEIXEIRA, JORGE F. LIMA; HENNING, PETRA; MAGALHAES, FERNANDO A. CINTRA; COLETTO-NUNES, GLAUCIA; FLORIANO-MARCELINO, THAIS; WESTERLUND, ANNA; MOVERARE-SKRTIC, SOFIA; OLIVEIRA, GUILHERME J. P. L.; LERNER, ULF H.; SOUZA, PEDRO PAULO C.. Osteoprotective effect by interleukin-4 (IL-4) on lipoprotein-induced periodontitis. CYTOKINE, v. 172, p. 9-pg., 2023-10-26. (14/05283-3)

SOUZA, PEDRO P. C.; LUNDBERG, PERNILLA; LUNDGREN, INGER; MAGALHAES, FERNANDO A. C.; COSTA-NETO, CLAUDIO M.; LERNER, ULF H.. Activation of Toll-like receptor 2 induces B1 and B2 kinin receptors in human gingival fibroblasts and in mouse gingiva. SCIENTIFIC REPORTS, v. 9, FEB 27 2019. (14/05283-3)

TEIXEIRA, JORGE FELIPE LIMA; DE SOUZA, JOAO ANTONIO CHAVES; MAGALHAES, FERNANDO AUGUSTO CINTRA; DE OLIVEIRA, GUILHERME JOSE PIMENTEL LOPES; DE SANTIS, JOSE BERNARDO; COSTA, CARLOS ALBERTO DE SOUZA; DE SOUZA, PEDRO PAULO CHAVES. Laser-Modified Ti Surface Improves Paracrine Osteogenesis by Modulating the Expression of DKK1 in Osteoblasts. JOURNAL OF FUNCTIONAL BIOMATERIALS, v. 14, n. 4, p. 12-pg., 2023-04-01. (14/05283-3, 17/22739-9)

HENNING, PETRA; MOVERARE-SKRTIC, SOFIA; WESTERLUND, ANNA; CHAVES DE SOUZA, PEDRO PAULO; FLORIANO-MARCELINO, THAIS; NILSSON, KARIN H.; EL SHAHAWY, MAHA; OHLSSON, CLAES; LERNER, ULF H.. WNT16 is Robustly Increased by Oncostatin M in Mouse Calvarial Osteoblasts and Acts as a Negative Feedback Regulator of Osteoclast Formation Induced by Oncostatin M. JOURNAL OF INFLAMMATION RESEARCH, v. 14, p. 4723-4741, 2021. (15/00410-0, 14/05283-3)

LEGUIZAMON, N. DA PONTE; DE MOLO, R. S.; COLETTO-NUNES, G.; NOGUEIRA, A. V. B.; ROCHA, V, S.; NEO-JUSTINO, D. M.; SOARES-COSTA, A.; CERRI, P. S.; LERNER, U. H.; SOUZA, P. P. C.; et al. hytocystatin CsinCPI-2 Reduces Osteoclastogenesis and Alveolar Bone Los. JOURNAL OF DENTAL RESEARCH, v. 101, n. 2, JUL 2021. (14/05283-3, 18/10727-9, 18/10728-5, 16/09876-4, 15/21697-5)

MOVERARE-SKRTIC, SOFIA; NILSSON, KARIN H.; HENNING, PETRA; FUNCK-BRENTANO, THOMAS; NETHANDER, MARIA; RIVADENEIRA, FERNANDO; NUNES, GLAUCIA COLETTO; KOSKELA, ANTTI; TUUKKANEN, JUHA; TUCKERMANN, JAN; et al. Osteoblast-derived NOTUM reduces cortical bone mass in mice and the NOTUM locus is associated with bone mineral density in humans. FASEB JOURNAL, v. 33, n. 10, p. 17-pg., 2019-10-01. (14/05283-3)