Identify, isolate and functionally characterize stromal cells derived of human lymph nodes

• Grant number: 14/15504-7
• Support Opportunities: Regular Research Grants
• Start date: November 01, 2014
• End date: April 30, 2017
• Field of knowledge: Biological Sciences - Immunology - Cellular Immunology
• Principal Investigator: Luciana Cavalheiro Marti
• Grantee: Luciana Cavalheiro Marti
• Host Institution: Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE). Sociedade Beneficente Israelita Brasileira Albert Einstein (SBIBAE). São Paulo , SP, Brazil
• Associated researchers: Camila Bononi de Almeida ; Luiz Vicente Rizzo ; Patricia Severino

Abstract

Lymph nodes are 400 small organs distributed along the body and play an import role in tolerance and immune response. These small organs are composed by a variety of cells, among these cells are the stromal cells, although scarcely studied they seems to play an important role in immunemodulation and peripheral tolerance. On the other hand, stromal cells derived from bone marrow have a performance in immunomodulation and has been used in graft versus host disease clinical trials. Our hypothesis is that stromal cells from lymph nodes has similar role as bone marrow mesenchymal cells, mainly in presence of an immune response already in course, behaving as sensors and switcher of immune response, not only interfering in modulation as well in survival and traffic of different cells from the immune system. The knowledge acquired studding the biology and function of these cells can provide better understanding of diseases such as GVHD, autoimmunity and infections. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

TORRES PALOMINO, DIANA CAROLINA; MARTI, LUCIANA CAVALHEIRO. Chemokines and immunity. Einstein (São Paulo), v. 13, n. 3, p. 469-473, JUL-SEP 2015. (14/15504-7)

SEVERINO, PATRICIA; PALOMINO, DIANA TORRES; ALVARENGA, HELIENE; ALMEIDA, CAMILA BONONI; PASQUALIM, DENISE CUNHA; CURY, ADRIANO; SALVALAGGIO, PAOLO ROGERIO; DE VASCONCELOS MACEDO, ANTONIO LUIZ; ANDRADE, MARIA CLAUDINA; ALOIA, THIAGO; et al. Human Lymph Node-Derived Fibroblastic and Double-Negative Reticular Cells Alter Their Chemokines and Cytokines Expression Profile Following Expression Profile Following. FRONTIERS IN IMMUNOLOGY, v. 8, FEB 14 2017. (14/15504-7)

TORRES PALOMINO, DIANA CAROLINA; MARTI, LUCIANA CAVALHEIRO. Chemokines and immunity. Einstein (São Paulo), v. 13, n. 3, p. 5-pg., 2015-07-01. (14/15504-7)