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Differential gene expression in stromal cells derived from bone marrow involved or uninvolved by malignant cells of breast cancer patients

Grant number: 06/00543-0
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): May 01, 2006
Effective date (End): April 30, 2007
Field of knowledge:Health Sciences - Medicine
Principal researcher:Maria Aparecida Azevedo Koike Folgueira
Grantee:Bárbara dos Santos Nunes
Home Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

The inter-relationship between epithelial cells and stromal cells from lymph nodes or bone marrow from patients with breast cancer is an unclear aspect. It is possible that soluble factors produced by fibroblasts from lymph nodes (LN) or bone marrow (BM) may influence the establishment of metastasis. We have initially evaluated the gene expression profile from fibroblasts from involved and uninvolved lymph nodes from breast cancer patients. We have also determined the influence of soluble factors produced by normal or malignant epithelial mammary cells on fibroblasts’ gene expression. Our next objective is to identify genes differentially expressed between stromal cells from involved or uninvolved BM.

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