The role myogenic precursor cells in skeletal myopathy-induced heart failure: effect of exercise training

• Grant number: 14/23703-0
• Support Opportunities: Regular Research Grants
• Start date: April 01, 2015
• End date: December 31, 2017
• Field of knowledge: Health Sciences - Physical Education
• Principal Investigator: Patricia Chakur Brum
• Grantee: Patricia Chakur Brum
• Host Institution: Escola de Educação Física e Esporte (EEFE). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated researchers: Carlos Eduardo Negrão ; Niels Olsen Saraiva Câmara

Abstract

Heart failure (HF) is a common endpoint for many forms of cardiomyopathies and other cardiovascular diseases. Given its growing prevalence and associated morbimortality, HF is a relevant public heath problem. In advanced stages, HF leads to functional impairment and excessive loss of skeletal muscle mass; the latter strongly associated with a poor prognosis. Therefore, the molecular mechanisms underlying muscle wasting in HF are of main interest. The regulation of skeletal muscle mass is influenced by the ability of injured skeletal muscle to regenerate. In skeletal muscle regeneration process, the inflammatory response triggers the activation of satellite cells and precursors cell originated from blood marrow that ultimately lead to regeneration. However, there is a lack of information regarding the ability of these myogenic cell population counteract muscle wasting during the progression HF myopathy. Aerobic exercise training is an efficient non-pharmacological therapy for HF and it is known that aerobic exercise training is able to maintain/increase skeletal muscle mass of healthy individuals and restrain muscle wasting in HF patients. However, whether exercise training is able to revert (partially or totally) the HF myopathy by improving muscle regeneration process is still unknown. Therefore, the aim of this project is to test the hypothesis that aerobic exercise training will counteract muscle wasting in HF by improving muscle regeneration involving the participation of satellite cells as well as other progenitors cells populations.Geral (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

BOZI, LUIZ H. M.; JANNIG, PAULO R.; ROLIM, NATALE; VOLTARELLI, VANESSA A.; DOURADO, PAULO M. M.; WISLOFF, ULRIK; BRUM, PATRICIA C.. Aerobic exercise training rescues cardiac protein quality control and blunts endoplasmic reticulum stress in heart failure rats. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, v. 20, n. 11, p. 2208-2212, NOV 2016. (10/50048-1, 14/23703-0)

BOZI, LUIZ H. M.; JANNIG, PAULO R.; ROLIM, NATALE; VOLTARELLI, VANESSA A.; DOURADO, PAULO M. M.; WISLOFF, ULRIK; BRUM, PATRICIA C.. Aerobic exercise training rescues cardiac protein quality control and blunts endoplasmic reticulum stress in heart failure rats. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, v. 20, n. 11, p. 5-pg., 2016-11-01. (14/23703-0, 10/50048-1)

CUNHA, TELMA F.; BECHARA, LUIZ R. G.; BACURAU, ALINE V. N.; JANNIG, PAULO R.; VOLTARELLI, VANESSA A.; DOURADO, PAULO M.; VASCONCELOS, ANDREA R.; SCAVONE, CRISTOFORO; FERREIRA, JULIO C. B.; BRUM, PATRICIA C.. Exercise training decreases NADPH oxidase activity and restores skeletal muscle mass in heart failure rats. Journal of Applied Physiology, v. 122, n. 4, p. 817-827, APR 2017. (12/05765-2, 14/23703-0, 11/00728-9)