The aim of this project is based on the use of transgenic lines of Ae. aegypti, to be adding methodology of dengue control already used. The results showed that the strain OX513A reduction strategy is viable to reduce mosquitoes population. However, it is unique and can be improved. Our strategy is based on the creation and use of three strains of genetically modified Ae. aegypti. The first act in suppressing populations (male sterile) in association with the second strain that is genetically modified to produce only males (female sex reversion - GSS) and the third acting in introducing gene (Virus-lethal)In terms of innovation and improvement in population suppression, our strain have two points: the first is that for the production of male-sterile, tetracycline not be used in mass production (only in the colonies), thereby reducing the cost of production thus as the treatment of produced water. In addition to obtaining the GSS strain (males only) would not need to physically separate the males from the females and 100% of the production will be released, greatly improving the efficiency of the process. (AU)
Articles published in Pesquisa FAPESP Magazine about the research grant:
COSTA-DA-SILVA, ANDRE LUIS;
IOSHINO, RAFAELLA SAYURI;
CORREA DE ARAUJO, HELENA ROCHA;
KOJIN, BIANCA BURINI;
DE ANDRADE ZANOTTO, PAOLO MARINHO;
LEAL OLIVEIRA, DANIELLE BRUNA;
MELO, STELLA REZENDE;
DURIGON, EDISON LUIZ;
CAPURRO, MARGARETH LARA.
Laboratory strains of Aedes aegypti are competent to Brazilian Zika virus.
FEB 10 2017.
Web of Science Citations: 17.
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