| Grant number: | 15/08782-3 |
| Support Opportunities: | Regular Research Grants |
| Duration: | July 01, 2015 - June 30, 2017 |
| Field of knowledge: | Biological Sciences - Biochemistry - Chemistry of Macromolecules |
| Principal Investigator: | Marcelo Andrade de Lima |
| Grantee: | Marcelo Andrade de Lima |
| Host Institution: | Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil |
| Associated researchers: | Edwin Alexander Yates ; Helena Bonciani Nader |
Abstract
Heparan sulfate (HS), a sulfated linear carbohydrate which decorates the cell surface and extracelullar matrix, are ubiquitously distributed throughout the animal kingdom and represent a key regulator of biological processes as well as a vast, largely untapped, reservoir of potential therapeutic agents. Dynamic temporal and spatial variations in HS structure underpin the concept of the 'heparanome', and a complex HS interactome. Understanding its structure, composition and biosynthesis is vital for comprehensive structure-function parallel of HS-protein interactions. In this project, we will investigate the structure of HS in different relevant biological models in order to understand their possible biosynthetic pathways to map HS structures relevant to biological processes. Furthermore, using spectroscopic and stopped-flow techniques, we will investigate the extent and nature of the specificity of HS-protein interactions in a conformational perspective with no inherent bias. (AU)
| Articles published in Agência FAPESP Newsletter about the research grant: |
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