Prevalence of Restless limb movements, cognitive abnormalities and quality of life in juvenile fibromyalgia

• Grant number: 13/18909-5
• Support Opportunities: Regular Research Grants
• Start date: July 01, 2015
• End date: June 30, 2017
• Field of knowledge: Humanities - Psychology - Psychological Treatment and Prevention
• Principal Investigator: Claudio Arnaldo Len
• Grantee: Claudio Arnaldo Len
• Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil
• Associated researchers: Flávia Heloísa Dos Santos ; Gustavo Antonio Moreira ; Maria Teresa de Sande e Lemos Ramos Ascensão Terreri

Abstract

Restless limb syndrome (RLS) is characterized by an unpleasant feeling and/or uncontrollable impulse to move the legs or arms. RLS can occur among those who suffer from joint and muscle diseases such as fibromyalgia (FM). The FM is characterized by widespread chronic/recurrent pain, especially in tender points, predetermined by emotional and affective component. The hypothesis is that the SPI prevail in girls and that patients with FM have more sleep disturbances and cognitive decline (memory and attention). Our results may have influence on the paradigm of care in specialized ambulatory monitoring of children and adolescents with pain, contributing to a more effective and more likely to succeed. Objectives: Objectives: To investigate the frequency of RLS in adolescents with and without FM. Check if there is a pattern of sleep alterations more common in adolescents with juvenile FM, if they exhibit deficits in cognitive functions and quality of life related to health status. It will also be translated the Pediatric Restless Legs Syndrome (RSL) Severity Scale and Parent Questionnaire. Methods: It will be assessed by means of controlled cross-sectional study, 58 adolescents aged 12-16 years, female, arranged in two groups, "pain" (n = 29) diagnosed with FM, for at least six months and control group (n = 29) apparently healthy, without complaint of pain. All teens will perform clinical evaluation, anamnesis, and application of neuropsychological tests, polysomnography and clinical analysis in blood. The methodology will be combined different approaches: laboratory, neurophysiological and cognitive, which may be useful for identifying and confirming the diagnosis and provide more information about the impacts of the syndromes presented. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MOREIRA, G. A.; AMORIM, R. A.; TERRERI, M. T.; MOLINA, J.; TUFIK, S.; LEN, C. A.. SLEEP AND RESTLESS LEGS SYNDROME IN ADOLESCENTS WITH IDIOPATHIC MUSCULOSKELETAL PAIN. Sleep Medicine, v. 40, p. 2-pg., 2017-12-01. (13/18909-5)