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Evaluation of pain and anesthetic efficacy after topical application of microneedles: a randomized clinical trial

Grant number: 15/50004-8
Support type:Regular Research Grants
Duration: July 01, 2015 - June 30, 2018
Field of knowledge:Health Sciences - Dentistry - Dental Clinics
Cooperation agreement: Texas Tech University
Mobility Program: SPRINT - Projetos de pesquisa - Mobilidade
Principal Investigator:Michelle Franz Montan Braga Leite
Grantee:Michelle Franz Montan Braga Leite
Principal investigator abroad: Harvinder Singh Gill
Institution abroad: Texas Tech University (TTU), United States
Home Institution: Faculdade de Odontologia de Piracicaba (FOP). Universidade Estadual de Campinas (UNICAMP). Piracicaba , SP, Brazil
Associated research grant:12/06974-4 - Development, biocompatibility and permeation studies on gel formulations of poly-epsilon-caprolactone nanocapsules containing local anesthetics, AP.JP


This current proposal aims to evaluate the feasibility of microneedles (MNs) as a drug delivery device at the oral mucosa to enable topical anesthesia. In Dentistry, topical anesthesia is performed prior to deep injection of local anesthesia. However, due (AU)

Matéria(s) publicada(s) na Agência FAPESP sobre o auxílio:
Microneedles can increase the effectiveness of topical anesthesia used in dentistry 

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SANTOS, STEPHANY DI CARLA; FAVARO-MOREIRA, NADIA CRISTINA; ABDALLA, HENRIQUE BALLASSIN; XAVIER AUGUSTO, GABRIELA GAMA; COSTA, YURI MARTINS; VOLPATO, MARIA CRISTINA; GROPPO, FRANCISCO CARLOS; GILL, HARVINDER SINGH; FRANZ-MONTAN, MICHELLE. A crossover clinical study to evaluate pain intensity from microneedle insertion in different parts of the oral cavity. International Journal of Pharmaceutics, v. 592, JAN 5 2021. Web of Science Citations: 0.

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